ArticleJournal of molecular and cellular cardiology2011
Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.
Article in Journal of molecular and cellular cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure.American journal of physiology. Heart and circulatory physiology · 2012Trial
- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Bayliss Starling Prize Lecture 2023: Neuropeptide-Y being 'unsympathetic' to the broken hearted.The Journal of physiology · 2025Article
- Neurochemical alterations of intrinsic cardiac ganglionated nerve plexus caused by arterial hypertension developed during ageing in spontaneously hypertensive and Wistar Kyoto rats.Journal of anatomy · 2023Article
- Effects of chronic cholinergic stimulation associated with aerobic physical training on cardiac morphofunctional and autonomic parameters in spontaneously hypertensive rats.Scientific reports · 2021Article
- Neurotransmitter Switching Coupled to β-Adrenergic Signaling in Sympathetic Neurons in Prehypertensive States.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Increased Gi protein signaling potentiates the negative chronotropic effect of adenosine in the SHR right atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Angiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats.World journal of hepatology · 2017Article
- Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.Scientific reports · 2016Article
- C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.Cardiovascular research · 2016Article
- Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cardiac sympatho-vagal balance and ventricular arrhythmia.Autonomic neuroscience : basic & clinical · 2016Review
- Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.The Journal of physiology · 2016Review
- (-)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats.Oxidative medicine and cellular longevity · 2016Article
- Cardiac NO signalling in the metabolic syndrome.British journal of pharmacology · 2015Review
- Effect of pravastatin on echocardiographic circulation parameters in dogs.The Journal of veterinary medical science · 2014Article
- Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat.American journal of physiology. Heart and circulatory physiology · 2013Article
- Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Interplay between statins and PPARs in improving cardiovascular outcomes: a double-edged sword?British journal of pharmacology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is associated with heightened cardiac sympathetic drive whilst statins reduce angiotensin II (ATII) signalling, superoxide anion production and increase nitric oxide bioavailability, events that can potentially reduce peripheral cardiac sympathetic neurotransmission. We therefore investigated whether pravastatin alters peripheral cardiac sympathetic control in the spontaneously hypertensive rat (SHR). SHRs (16-18 weeks) had significantly (p<0.05) enhanced atrial (3)H-norepinephrine ((3)H-NE) release to field stimulation compared to normotensive WKYs. 2-week pravastatin supplementation significantly reduced (3)H-NE release to levels observed in the WKY. In-vivo, pravastatin lowered resting heart rate (HR) in the SHR despite not affecting arterial blood pressure or serum cholesterol. In SHR atria/right stellate ganglion preparations, the HR response to stellate stimulation (1, 3, and 5 Hz) was also significantly reduced by pravastatin whilst the HR response to exogenous NE (0.025-5 μmol) remained similar. The nitric oxide synthase (NOS) inhibitor l-NAME (1 mmol/l) increased (3)H-NE release by similar amounts in atria from supplemented and non-supplemented SHRs, whilst Western blotting showed no difference in protein levels of nNOS, eNOS, guanylyl cyclase, or the NADPH oxidase subunits Gp91 and P40 phox. Pravastatin significantly reduced cardiac ATII levels and angiotensin converting enzyme 1 and 2 expressions whilst protein levels of the ATII receptor (ATR(1)) remained unchanged in the SHR. Immunohistochemistry co-localised ATR(1) with tyrosine hydroxylase positive neurons in the stellate ganglion. The ATR(1) antagonist Losartan (5 μmol) equalised release of (3)H-NE to comparable levels in supplemented and non-supplemented SHRs. These results suggest 2-week pravastatin treatment reduces cardiac ATII, and prevents its facilitatory effect on NE release thus normalising cardiac sympathetic hyper-responsiveness in SHRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.