ArticleAdvances in genetics2010
In utero life and epigenetic predisposition for disease.
Article in Advances in genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
- Prenatal complications and sex modify the BMI-blood pressure relationship in children.Pediatric research · 2026Article
- In-utero and newborn factors and thyroid cancer incidence in adult women in the Sister Study cohort.British journal of cancer · 2025Observational
- Maternal Malnutrition and Elevated Disease Risk in Offspring.Nutrients · 2024Review
- ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.Pharmaceutics · 2023Review
- Role of microRNA in Endocrine Disruptor-Induced Immunomodulation of Metabolic Health.Metabolites · 2022Review
- Maternal and neonatal one-carbon metabolites and the epigenome-wide infant response.The Journal of nutritional biochemistry · 2022Article
- Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Maternal healthful dietary patterns during peripregnancy and long-term overweight risk in their offspring.European journal of epidemiology · 2020Article
- Article
- Markers as mediators: A review and synthesis of epigenetics literature.BioSocieties · 2019Article
- Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review.International journal of environmental research and public health · 2019Review
- In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice.Particle and fibre toxicology · 2019Article
- Elemental Metabolomics and Pregnancy Outcomes.Nutrients · 2019Review
- Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis.International journal of molecular sciences · 2018Article
- Maternal obesity impairs skeletal development in adult offspringThe Journal of endocrinology · 2018Article
- Maternal obesity aggravates the abnormality of porcine placenta by increasing NInternational journal of obesity (2005) · 2018Article
- Use of 5-azacytidine in a proof-of-concept study to evaluate the impact of pre-natal and post-natal exposures, as well as within generation persistent DNA methylation changes in Daphnia.Ecotoxicology (London, England) · 2018Article
- Associations between Global DNA Methylation and Telomere Length in Healthy Adolescents.Scientific reports · 2017Article
- A Framework to Address Challenges in Communicating the Developmental Origins of Health and Disease.Current environmental health reports · 2016Article
- Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review.Addiction biology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory regions of the human genome can be modified through epigenetic processes during prenatal life to make an individual more likely to suffer chronic diseases when they reach adulthood. The modification of chromatin and DNA contributes to a larger well-documented process known as "programming" whereby stressors in the womb give rise to adult onset diseases, including cancer. It is now well known that death from ischemic heart disease is related to birth weight; the lower the birth weight, the higher the risk of death from cardiovascular disease as well as type 2 diabetes and osteoporosis. Recent epidemiological data link rapid growth in the womb to metabolic disease and obesity and also to breast and lung cancers. There is increasing evidence that "marked" regions of DNA can become "unmarked" under the influence of dietary nutrients. This gives hope for reversing propensities for cancers and other diseases that were acquired in the womb. For several cancers, the size and shape of the placenta are associated with a person's cardiovascular and cancer risks as are maternal body mass index and height. The features of placental growth and nutrient transport properties that lead to adult disease have been little studied. In conclusion, several cancers have their origins in the womb, including lung and breast cancer. More research is needed to determine the epigenetic processes that underlie the programming of these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.