Evidence map›Paper›PMID 20933026›Full record

ReviewAdvanced drug delivery reviews

Intravital microscopy as a tool to study drug delivery in preclinical studies.

Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021
    Article
  3. Article
  4. Article
  5. Review
  6. Seeing Better and Going Deeper in Cancer Nanotheranostics.International journal of molecular sciences · 2019
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Imaging the dynamics of endocytosis in live mammalian tissues.Cold Spring Harbor perspectives in biology · 2014
    Review
  17. Review
  18. Review
  19. Intravital microscopy to image membrane trafficking in live rats.Methods in molecular biology (Clifton, N.J.) · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Panomwat AmornphimolthamIntracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, 30 Convent drive, Room 303A, Bethesda, MD 20892-4340, USA.
Andrius Masedunskas
Roberto Weigert
National Institute of Dental and Craniofacial Research · US

Funding

Molecular Mechanisms regulating membrane trafficking in salivary glandsZIADE000717 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WEIGERT, ROBERTO · 2009 to 2015
$9.2M
Intramural NIH HHS ZIA DE000717
6 · The paper itself

Abstract

The technical developments in the field of non-linear microscopy have made intravital microscopy one of the most successful techniques for studying physiological and pathological processes in live animals. Intravital microscopy has been utilized to address many biological questions in basic research and is now a fundamental tool for preclinical studies, with an enormous potential for clinical applications. The ability to dynamically image cellular and subcellular structures combined with the possibility to perform longitudinal studies have empowered investigators to use this discipline to study the mechanisms of action of therapeutic agents and assess the efficacy on their targets in vivo. The goal of this review is to provide a general overview of the recent advances in intravital microscopy and to discuss some of its applications in preclinical studies.

Indexed as

AnimalsDiagnostic ImagingDrug Delivery SystemsHumansLongitudinal StudiesMicroscopy

Identifiers

PMID20933026
PMCPMC3024442
OpenAlexW2033606302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.