ArticleMatrix biology : journal of the International Society for Matrix Biology2011
Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens.
Article in Matrix biology : journal of the International Society for Matrix Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Computational Design and Expression of Headless Influenza Hemagglutinin Antigens Toward a Modular Universal Nanoparticle Vaccine.Antibodies (Basel, Switzerland) · 2026Article
- Trimerization of CD40L-specific affibody molecules using collagen domains enhances target binding and CD40 blockade.Cellular and molecular life sciences : CMLS · 2026Article
- Ageing impacts extracellular matrix turnover and remodelling in the kidney.Matrix biology plus · 2026Article
- Phylogenomic analysis of the collagen-like BclA proteins inApplied and environmental microbiology · 2026Article
- Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Advances in Molecular Function and Recombinant Expression of Human Collagen.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Collagen formation, function and role in kidney disease.Nature reviews. Nephrology · 2025Review
- Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching.International journal of molecular sciences · 2024Review
- Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2023Article
- Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.The EMBO journal · 2021Article
- Collagen XV, a multifaceted multiplexin present across tissues and species.Matrix biology plus · 2020Article
- Structural insight for chain selection and stagger control in collagen.Scientific reports · 2016Article
- The crystal structure of the streptococcal collagen-like protein 2 globular domain from invasive M3-type group A Streptococcus shows significant similarity to immunomodulatory HIV protein gp41.The Journal of biological chemistry · 2014Article
- Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.Human molecular genetics · 2013Article
- Collagen XV: exploring its structure and role within the tumor microenvironment.Molecular cancer research : MCR · 2013Review
- Vascular Ehlers-Danlos syndrome mutations in type III collagen differently stall the triple helical folding.The Journal of biological chemistry · 2013Article
- The NC2 domain of type IX collagen determines the chain register of the triple helix.The Journal of biological chemistry · 2012Article
- Tumor suppression by collagen XV is independent of the restin domain.Matrix biology : journal of the International Society for Matrix Biology · 2012Article
- Improved stability of multivalent antibodies containing the human collagen XV trimerization domain.mAbsArticle
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5 authors.
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Abstract
Correct folding of the collagen triple helix requires a self-association step which selects and binds α-chains into trimers. Here we report the crystal structure of the trimerization domain of human type XV collagen. The trimerization domain of type XV collagen contains three monomers each composed of four β-sheets and an α-helix. The hydrophobic core of the trimer is devoid of solvent molecules and is shaped by β-sheet planes from each monomer. The trimerization domain is extremely stable and forms at picomolar concentrations. It is found that the trimerization domain of type XV collagen is structurally similar to that of type XVIII, despite only 32% sequence identity. High structural conservation indicates that the multiplexin trimerization domain represents a three dimensional fold that allows for sequence variability while retaining structural integrity necessary for tight and efficient trimerization.
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