ReviewBiochimica et biophysica acta2011
Calcium-mediated mechanisms of cystic expansion.
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Autosomal Dominant Polycystic Kidney Disease: Extrarenal Involvement.International journal of molecular sciences · 2024Review
- Clinical findings, underlying pathogenetic processes and treatment of vascular dysfunction in autosomal dominant polycystic kidney disease.Renal failure · 2023Review
- Inward CaAmerican journal of physiology. Renal physiology · 2021Article
- Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma.The Journal of investigative dermatology · 2019Article
- Urinary proteome signature of Renal Cysts and Diabetes syndrome in children.Scientific reports · 2019Article
- Article
- Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells.Scientific reports · 2018Article
- The native TRPP2-dependent channel of murine renal primary cilia.American journal of physiology. Renal physiology · 2017Article
- Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.Journal of the American Society of Nephrology : JASN · 2016Article
- A systematic comparison of mathematical models for inherent measurement of ciliary length: how a cell can measure length and volume.Biophysical journal · 2015Article
- Genome-wide linkage and exome analyses identify variants of HMCN1 for splenic epidermoid cyst.BMC medical genetics · 2014Article
- Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.British journal of pharmacology · 2014Article
- Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development.Human genetics · 2014Article
- Polycystins and cellular Ca2+ signaling.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Intracellular calcium release modulates polycystin-2 trafficking.BMC nephrology · 2013Article
- Non-motile primary cilia as fluid shear stress mechanosensors.Methods in enzymology · 2013Article
- Mechanisms regulating cilia growth and cilia function in endothelial cells.Cellular and molecular life sciences : CMLS · 2012Article
- Mechanosensory calcium signaling.Advances in experimental medicine and biology · 2012Review
- The mechanosensory role of primary cilia in vascular hypertension.International journal of vascular medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this review, we will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal cyst formation. Because cytosolic calcium also regulates an array of signaling pathways, we will first discuss cilia-induced calcium fluxes, followed by Wnt signaling that has attributed to much-discussed planar cell polarity. We will then look at the relationship between cytosolic calcium and cAMP as one of the most important aspects of cyst progression. The signaling of cAMP on MAPK and mTOR will also be discussed. We infer that while cilia-induced calcium fluxes may be the initial signaling messenger for various cellular pathways, no single signaling mediator or pathway is implicated exclusively in the progression of the cystic expansion. This article is part of a Special Issue entitled: Polycystic Kidney Disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.