ArticleImmunology letters2011
Modeling Sjögren's syndrome with Id3 conditional knockout mice.
Article in Immunology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- E proteins control the development of NKγδT cells through their invariant T cell receptor.Nature communications · 2024Article
- Article
- Inhibition of NLRP3 inflammasome activity by MCC950 leads to exacerbation of Sjӧgren's syndrome pathologies in non-obese diabetic mice.Immunology · 2023Article
- ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.Cell death & disease · 2022Article
- Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.The Journal of experimental medicine · 2022Article
- Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases.International journal of molecular sciences · 2021Review
- A mosaic analysis system with Cre or Tomato expression in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Heterogenous Populations of Tissue-Resident CD8Immunity · 2020Article
- Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren's syndrome.Cell death & disease · 2020Article
- Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Update on Pathogenesis of Sjogren's Syndrome.Current rheumatology reviews · 2017Review
- Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease.BioMed research international · 2017Review
- Id3 Orchestrates Germinal Center B Cell Development.Molecular and cellular biology · 2016Article
- Specification of tissue-resident macrophages during organogenesis.Science (New York, N.Y.) · 2016Article
- Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.Nature immunology · 2016Article
- Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Mouse Models of Primary Sjogren's Syndrome.Current pharmaceutical design · 2015Review
- Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The Id3 gene has been shown to play important roles in the development and function of broad tissue types including B and T cells. Id3 deficient mice develop autoimmune disease similar to human Sjögren's syndrome. Both B and T lymphocytes have been implicated to contribute to the disease phenotype in this disease model. In order to gain a better understanding of individual cell types in this disease model, we generated an Id3 conditional allele. An LckCre transgene was used to induce Id3 deletion in developing T cells. We showed that the Id3 gene was efficiently disrupted in early thymocyte development prior to T cell receptor (TCR)-mediated positive selection. Consequently, thymocyte maturation was impaired in the conditional knockout mice. These mice developed exocrinopathy starting at two months of age and subsequently exhibited high incidence of lymphocyte infiltration to salivary glands between eight and 12 months of age. This progressive feature of disease development is very similar to those observed in Id3 germline knockout mice. This study establishes a new model for investigating the relationship between T cell development and autoimmune disease. Our observation provides an experimental case that autoimmune disease may be induced by acquired mutation in developing T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.