ArticleLipids in health and disease2010
Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model.
Article in Lipids in health and disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
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- Caiman's fat enriched with n-3 fatty acids: potential food supplement.Tropical animal health and production · 2023Article
- 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword.Lipids in health and disease · 2021Review
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- Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2019Review
- Natural Products to Fight Cancer: A Focus onToxins · 2018Review
- Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation.Cell death & disease · 2018Article
- Can nut consumption improve colon cancer survival?Translational gastroenterology and hepatology · 2018Article
- Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor.Medicine · 2017Observational
- Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.Cytotechnology · 2016Article
- Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics.International journal of nanomedicine · 2015Article
- Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice.Laboratory animal research · 2013Article
- The influence of Cox-2 and bioactive lipids on hematological cancers.Current angiogenesis · 2013Article
- Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer.International journal of colorectal disease · 2013Article
- Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro.Lipids in health and disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNutritional factors play a major role in cancer initiation and development. Dietary polyunsaturated fatty acids (PUFAs) have the ability to induce modifications in the activity of lipoxygenase (LOX) and cyclooxygenase (COX) enzymes that affect tumour growth. We studied the effect of two diets enriched in 6% Walnut and Peanut oils that are rich in ω-3 and ω9 PUFAs respectively on a murine mammary gland adenocarcinoma as compared with the control (C) that received commercial diet.
resultsPeanut oil enriched diet induced an increase in membrane arachidonic acid (AA) content and the cyclooxygenase enzyme derived 12-HHT (p < 0.05) and simultaneously showed decrease in 12-LOX, 15-LOX-2, 15-LOX-1 and PGE activities (p < 0.05) that corresponded to higher apoptosis and lower mitosis seen in this group (p < 0.05). Furthermore, Peanut oil group showed lower T-cell infiltration (p < 0.05), number of metastasis (p < 0.05) and tumour volume (p < 0.05) and longer survival rate compared to other groups.
conclusionsThe results of the present study showed that Peanut oil-enriched diet protects against mammary cancer development by modulating tumour membrane fatty acids composition and LOX and COX enzyme activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.