ArticleThe Journal of infectious diseases2010
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Epidemiology of invasiveInternational journal of circumpolar health · 2022Article
- Long Term Impact of Conjugate Vaccines onMicroorganisms · 2021Review
- A Narrative Review of the Molecular Epidemiology and Laboratory Surveillance of Vaccine Preventable Bacterial Meningitis Agents:Microorganisms · 2021Review
- Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Blood-Brain Barrier in a Haemophilus influenzae Type a In Vitro Infection: Role of Adenosine Receptors AMolecular neurobiology · 2018Article
- [Non-type b Haemophilus influenzae: a rare cause of meningitis in an infant with a guarded prognosis].The Pan African medical journal · 2018Article
- Haemophilus influenzae Type a Meningitis in Immunocompetent Child, Oman, 2015.Emerging infectious diseases · 2017Article
- Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil.Memorias do Instituto Oswaldo Cruz · 2017Article
- A review of invasive Haemophilus influenzae disease in the Indigenous populations of North America.Epidemiology and infection · 2014Review
- Distribution of strain type and antimicrobial susceptibility of Escherichia coli isolates causing meningitis in a large urban setting in Brazil.Journal of clinical microbiology · 2014Article
- Haemophilus influenzae serotype a invasive disease, Alaska, USA, 1983-2011.Emerging infectious diseases · 2013Article
- Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2013Article
- The epidemiology of invasive disease due to Haemophilus influenzae serotype a in the Canadian North from 2000 to 2010.International journal of circumpolar health · 2013Article
- Emergence of non-serotype b encapsulated Haemophilus influenzae as a cause of pediatric meningitis in northwestern Ontario.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2013Article
- Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates.PloS one · 2011Article
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
Since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.
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