ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Xenopus sonic hedgehog guides retinal axons along the optic tract.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Prosomeric classification of retinorecipient centers: a new causal scenario.Brain structure & function · 2022Review
- Studying In Vivo Retinal Progenitor Cell Proliferation in Xenopus laevis.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.Cellular signalling · 2018Article
- Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice.Drug design, development and therapy · 2018Article
- Neurovascular patterning cues and implications for central and peripheral neurological disease.Surgical neurology international · 2017Review
- Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Developmental origin of patchy axonal connectivity in the neocortex: a computational model.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- cAMP-induced expression of neuropilin1 promotes retinal axon crossing in the zebrafish optic chiasm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance.Frontiers in cellular neuroscience · 2013Article
- Sonic hedgehog is indirectly required for intraretinal axon pathfinding by regulating chemokine expression in the optic stalk.Development (Cambridge, England) · 2012Article
- Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion.Cell research · 2012Article
- Nitric oxide as a putative retinal axon pathfinding and target recognition cue in Xenopus laevis.Impulse (Columbia, S.C.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The role of classic morphogens such as Sonic hedgehog (Shh) as axon guidance cues has been reported in a variety of vertebrate organisms (Charron and Tessier-Lavigne [2005] Development 132:2251-2262). In this work, we provide the first evidence that Xenopus sonic hedgehog (Xshh) signaling is involved in guiding retinal ganglion cell (RGC) axons along the optic tract. Xshh is expressed in the brain during retinal axon extension, adjacent to these axons in the ventral diencephalon. Retinal axons themselves express Patched 1 and Smoothened co-receptors during RGC axon growth. Blocking Shh signaling causes abnormal ventral pathfinding, and targeting errors at the optic tectum. Misexpression of exogenous N-Shh peptide in vivo also causes pathfinding errors. Retinal axons grown in culture respond to N-Shh in a dose-dependent manner, either by decreasing extension at lower concentrations, or retracting axons in the presence of higher doses. These data suggest that Shh signaling is required for normal RGC axon pathfinding and tectal targeting in the developing visual system of Xenopus. We propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.