Evidence map›Paper›PMID 20931575›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2010

Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

Jason C Kwan, Hendrik Luesch

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jason C KwanDepartment of Medicinal Chemistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA.
Hendrik Luesch

Funding

Chemistry and Biology of LargazolesR01CA138544 · NCI · UNIVERSITY OF FLORIDA · PI HONG, JIYONG, LUESCH, HENDRIK · 2009 to 2012
$1.2M
Activation of the Cancer Preventive Nrf2-ARE Pathway by SeaweedR21CA133681 · NCI · UNIVERSITY OF FLORIDA · PI LUESCH, HENDRIK · 2008 to 2009
$357k
NCI NIH HHS R01 CA138544NCI NIH HHS R21 CA133681PHS HHS P41M806210PHS HHS R01A138544PHS HHS R21A133681
6 · The paper itself

Abstract

Bioactive natural products often possess uniquely functionalized structures with unusual modes of action; however, the natural product itself is not always the active species. We discuss molecules that draw on protecting group chemistry or else require activation to unmask reactive centers, illustrating that nature is not only a source of complex structures but also a guide for elegant chemical transformations which provides ingenious chemical solutions for drug delivery.

Indexed as

Biological ProductsBleomycinCombinatorial Chemistry TechniquesHistone Deacetylase InhibitorsHumansMacrolidesMolecular StructureProdrugsBiological ProductsBleomycinHistone Deacetylase InhibitorsMacrolidesProdrugs

Identifiers

PMID20931575
PMCPMC7301413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.