ArticleJournal of neural transmission (Vienna, Austria : 1996)2011
Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Enriched Environment Regulates Dendritic Cells to Alleviate Inflammation in Cerebral Infarction Lesions.Computational and mathematical methods in medicine · 2021Article
- MicroRNA regulation in hypoxic environments: differential expression of microRNAs in the liver of largemouth bass (Micropterus salmoides).Fish physiology and biochemistry · 2020Article
- Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway.Molecular neurobiology · 2018Article
- Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats.Experimental and therapeutic medicine · 2017Article
- Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats.International journal of molecular sciences · 2017Article
- Tactile stimulation during development alters the neuroanatomical organization of the optic nerve in normal rats.Experimental brain research · 2016Article
- Environmental enrichment decreases asphyxia-induced neurobehavioral developmental delay in neonatal rats.International journal of molecular sciences · 2013Article
- Exposure to enriched environment decreases neurobehavioral deficits induced by neonatal glutamate toxicity.International journal of molecular sciences · 2013Article
- Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury.Tissue engineering. Part A · 2013Article
- Gender-dependent effects of enriched environment and social isolation in ischemic retinal lesion in adult rats.International journal of molecular sciences · 2013Article
- Bench to cribside: the path for developing a neuroprotectant.Translational stroke research · 2013Review
- Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required.Frontiers in cellular neuroscience · 2013Article
- Reorganization in processing of spectral and temporal input in the rat posterior auditory field induced by environmental enrichment.Journal of neurophysiology · 2012Article
- Angiogenic signalling pathways altered in gliomas: selection mechanisms for more aggressive neoplastic subpopulations with invasive phenotype.Journal of signal transduction · 2012Article
- Protective Effects of Enriched Environment Against Transient Cerebral Ischemia-Induced Impairment of Passive Avoidance Memory and Long-Term Potentiation in Rats.Basic and clinical neuroscienceArticle
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postnatal development of the visual cortex is modulated by experience, especially during the critical period. In rats, a stable neuronal population is only acquired after this relatively prolonged period. Vascular endothelial growth factor (VEGF) is the most important angiogenic factor and also has strong neuroprotective, neurotrophic and neurogenic properties. Similar effects have been described for rearing in enriched environments. Our aim is to investigate the vascular and neuronal effects of combining VEGF infusion and environmental enrichment on the visual cortex during the initial days of the critical period. Results showed that a small percentage of Cleaved Caspase-3 positive cells colocalized with neuronal markers. The lesion produced by the cannula implantation resulted in decreased vascular, neuronal and Caspase-3 positive cell densities. Rearing under enriched environment was unable to reverse these effects in any group, whereas VEGF infusion alone partially corrected those effects. A higher effectiveness was reached by combining both the procedures, the most effective combination being when enriched-environment rearing was introduced only after minipump implantation. In addition to the angiogenic effect of VEGF, applied strategies also had synergic neuroprotective effects, and the combination of the two strategies had more remarkable effects than those achieved by each strategy applied individually.
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