ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011
Clinical factors predicting bacteremia in low-risk febrile neutropenia after anti-cancer chemotherapy.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT.Health technology assessment (Winchester, England) · 2024Trial
- The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis.International journal of clinical oncology · 2026Article
- Successful Management of Neutropenic Sepsis Is Key to Better Survival of Patients With Blood Cancer in Sri Lanka: Real-World Data From the Resource-Limited Setting.JCO global oncology · 2024Article
- Risk factors for bacteremia in children with febrile neutropeniaTurkish journal of medical sciences · 2019Article
- Optimizing Symptoms and Management of Febrile Neutropenia among Cancer Patients: Current Status and Future Directions.Current oncology reports · 2017Review
- Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline.Current oncology (Toronto, Ont.) · 2016Article
- Bacterial bloodstream infections and antimicrobial susceptibility pattern in pediatric hematology/oncology patients after anticancer chemotherapy.Infection and drug resistance · 2014Article
- A pilot study of the efficacy and safety of empiric daptomycin therapy in oncology patients with fever and severe neutropenia.Therapeutic advances in infectious disease · 2013Article
- Adding procalcitonin to the MASCC risk-index score could improve risk stratification of patients with febrile neutropenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Observational
- The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBacteremia is an important clinical condition in febrile neutropenia that can cause clinical failure of antimicrobial therapy. The purpose of this study was to investigate the clinical factors predictive of bacteremia in low-risk febrile neutropenia at initial patient evaluation.
methodsWe performed a retrospective cohort study in a university hospital in Seoul, Korea, between May 1995 and May 2007. Patients who met the criteria of low-risk febrile neutropenia at the time of visit to emergency department after anti-cancer chemotherapy were included in the analysis.
resultsDuring the study period, 102 episodes of bacteremia were documented among the 993 episodes of low-risk febrile neutropenia. Single gram-negative bacteremia was most frequent. In multivariate regression analysis, initial body temperature ≥39°C, initial hypotension, presence of clinical sites of infection, presence of central venous catheter, initial absolute neutrophil count <50/mm(3), and the CRP ≥10 mg/dL were statistically significant predictors for bacteremia. A scoring system using these variables was derived and the likelihood of bacteremia was well correlated with the score points with AUC under ROC curve of 0.785. Patients with low score points had low rate of bacteremia, thus, would be candidates for outpatient-based or oral antibiotic therapy.
conclusionsWe identified major clinical factors that can predict bacteremia in low-risk febrile neutropenia.
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