ReviewNature reviews. Urology2010
Management of overactive bladder.
Review in Nature reviews. Urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The placebo effect in overactive bladder syndrome.Nature reviews. Urology · 2011Pooled it
- Association between the Urinary Bladder Volume and the Incidence of "De Novo" Overactive Bladder in Patients with Stress Urinary Incontinence Subjected to Sling Surgeries or Burch Procedure.BioMed research international · 2019Trial
- Chronic stable recording of physiologically evoked neural activity in a mixed autonomic nerve in awake, freely moving normal and experimental cystitis rats.APL bioengineering · 2026Article
- Exploring the association between weight-adjusted-waist index and overactive bladder: A population-based study.Medicine · 2026Article
- Urodynamic characteristics and clinical significance of detrusor overactivity in early (≤6 months) male urinary incontinence following TURP and RARP: a descriptive analysis of two cohorts.Frontiers in oncology · 2026Article
- Real-time prediction of bladder urine leakage using fuzzy inference system and dual Kalman filtering in cats.Scientific reports · 2024Article
- Mediterranean Diet and Overactive Bladder.International neurourology journal · 2022Article
- A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats.Scientific reports · 2021Article
- Comprehensive Review of Effective Application of Questionnaires for Clinical Research on Lower Urinary Tract Symptoms With Translation and Cultural Adaptation to the Korean Language.International neurourology journal · 2020Article
- Italian real-life clinical setting: the persistence and adherence with mirabegron in women with overactive bladder.International urology and nephrology · 2020Article
- A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.Molecules (Basel, Switzerland) · 2020Article
- Role of the brain stem in tibial inhibition of the micturition reflex in cats.American journal of physiology. Renal physiology · 2015Article
- Somatic modulation of spinal reflex bladder activity mediated by nociceptive bladder afferent nerve fibers in cats.American journal of physiology. Renal physiology · 2014Article
- Sex differences in the physiology and pharmacology of the lower urinary tract.Current urology · 2013Review
- Alteration in TRPV1 and Muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells.Acta physiologica (Oxford, England) · 2013Article
- Effects of kinin B(1) and B(2) receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats.British journal of pharmacology · 2012Article
- Management of lower urinary tract dysfunction in patients with neurological disorders.Korean journal of urology · 2012Article
- Electrical nerve stimulation for overactive bladder in children.Nature reviews. Urology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many people are affected by urinary urgency, which can be highly bothersome. Urgency is the cornerstone symptom of overactive bladder (OAB), commonly occurring in conjunction with urinary frequency and nocturia. Once other medical causes of similar symptoms have been excluded, first-line OAB management comprises fluid intake advice and bladder training, supplemented by antimuscarinic drugs if necessary. Urodynamic confirmation of the diagnosis is required for OAB patients whose symptoms are refractory to first-line interventions. If patients are severely bothered by OAB despite optimization of medical treatment, they may proceed to invasive treatments, including neuromodulation, enterocystoplasty, detrusor myectomy, or urinary diversion. Our burgeoning understanding of the complex cellular, neural and integrative physiology of the bladder offers new insights into the causative mechanisms of OAB, and reasons why patients sometimes fail to respond to treatment. Study of sensory information pathways in the lower urinary tract has led to identification of the urothelium, afferent nerves and interstitial cells as key cellular elements in OAB. In-depth knowledge of the hierarchy of central nervous system control is lacking, but functional imaging is beginning to elucidate the challenges that lie ahead. New treatments under investigation include botulinum neurotoxin-A injection, oral β(3)-adrenergic agonists, and novel modalities for nerve stimulation. The subjective nature of urinary urgency, the lack of animal models and the multifactorial pathophysiology of OAB present significant challenges to effective clinical management.
Indexed as
Identifiers
20930868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.