Evidence map›Paper›PMID 20930754›Full record

ArticleNature medicine2010

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy.

Napoleone Ferrara

3 registry-linked trialsAbstract readAutobiographyBiographyHistorical Article
PubMed Publisher
In one paragraph

Article in Nature medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 111 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02873351 phase2withdrawnnot on this mapstarted 2019, after this paper: background citation

Pilot Study of L-DOPA Safety and Tolerability in Patients With AMD, and Proof of Concept That L-DOPA Improves Surrogate Biomarkers in Patients With Moderate to Advanced AMD

TypeinterventionalSponsorSnyder, Robert W., M.D., Ph.D., P.C.Ran2019 to 2020Enrolled0ConditionsAge-related Macular DegenerationArmscarbidopa-levodopa 25-100 mg, placebo for carbidopa-levodopa 25-100 mg
NCT03022318 phase2completednot on this mapstarted 2017, after this paper: background citation

Short Term Effects of Carbidopa-levodopa in Neovascular AMD

TypeinterventionalSponsorSnyder, Robert W., M.D., Ph.D., P.C.Ran2017 to 2020Enrolled20ConditionsAge-related Macular DegenerationArmscarbidopa-levodopa 25-100 mg tablets
NCT03023059 phase2completednot on this mapstarted 2017, after this paper: background citation

Proof of Concept and Dose Ranging Study of Carbidopa-levodopa in Neovascular AMD

TypeinterventionalSponsorSnyder, Robert W., M.D., Ph.D., P.C.Ran2017 to 2020Enrolled35ConditionsAge-related Macular DegenerationArmsCarbidopa-Levodopa, 25 Mg-100 Mg Oral Tablet
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Mathematical Models of Topically and Intravitreally Applied Ranibizumab.Investigative ophthalmology & visual science · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Impact of umbelliprenin-containing niosome nanoparticles onInternational journal of ophthalmology · 2024
    Article
  19. Article
  20. Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Napoleone FerraraGenentech, South San Francisco, California, USA. nf@gene.com

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedClinical Trials as TopicEndocrinologyHistory, 20th CenturyHistory, 21st CenturyHumansMacular DegenerationRanibizumabRetinal NeovascularizationUnited StatesVascular Endothelial Growth Factor AAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedRanibizumabVascular Endothelial Growth Factor A

Identifiers

PMID20930754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.