ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2010
Airway platelet activation is associated with airway eosinophilic inflammation in asthma.
Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Platelet Response to Allergens, CXCL10, and CXCL5 in the Context of Asthma.ACS bio & med chem Au · 2023Article
- An Insight into Recent Advances on Platelet Function in Health and Disease.International journal of molecular sciences · 2022Review
- Identification of the molecular subgroups in asthma by gene expression profiles: airway inflammation implications.BMC pulmonary medicine · 2022Article
- Emerging Roles of Platelets in Allergic Asthma.Frontiers in immunology · 2022Review
- Review
- The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma.Clinical and molecular allergy : CMA · 2021Article
- The GRKs Reactome: Role in Cell Biology and Pathology.International journal of molecular sciences · 2021Review
- The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic.Frontiers in molecular biosciences · 2020Review
- The synergistic effects of clopidogrel with montelukast may be beneficial for asthma treatment.Journal of cellular and molecular medicine · 2019Article
- Platelet-Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma.Frontiers in medicine · 2017Review
- Sex differences in the association between neck circumference and asthma.Pediatric pulmonology · 2016Observational
- Platelets promote allergic asthma through the expression of CD154.Cellular & molecular immunology · 2015Article
- Integrating microbial and host transcriptomics to characterize asthma-associated microbial communities.BMC medical genomics · 2015Article
- Extracellular cyclophilin levels associate with parameters of asthma in phenotypic clusters.The Journal of asthma : official journal of the Association for the Care of Asthma · 2011Article
- Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAllergic asthma is characterized by airway inflammation associated with recruitment and activation of eosinophils. In mice, allergen exposure induces platelet migration to the airways that is necessary for eosinophil recruitment and activation. We therefore hypothesized that in the airways of human subjects with asthma, platelet activation would be positively associated with eosinophil activation and platelet and eosinophil activation would both be associated with clinical asthma characteristics.
methodsNasal wash levels of P-selectin (a measure of platelet activation) and eosinophil cationic protein (ECP) (a measure of eosinophil activation) were compared with each other and with clinical asthma characteristics in a cross-sectional study of urban children and adolescents (age range, 6-20 years) with asthma.
resultsRegression analysis revealed a significantly positive association between log10 P-selectin levels and log10 ECP levels (β = 0.50 ng/mL [95% confidence interval, 0.05-0.94 ng/mL]; P = 0.029). Additionally, ECP was significantly and negatively associated with 2 asthma-related quality of life measurements, and P-selectin was associated with one of these.
conclusionsOur study shows the first significant association between platelet and eosinophil activation in airways of human subjects with asthma. These data provide a first step toward delineating what seems to be an important role for platelets in airway eosinophilia.
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Registered trials
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