ArticleCell cycle (Georgetown, Tex.)2010
A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- A phase oscillator model of cell cycles reveals nuclear density control in a branched fungal network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Asynchronous nuclear cycles in multinucleatedScience advances · 2022Article
- Skeletal muscle fibers count on nuclear numbers for growth.Seminars in cell & developmental biology · 2021Review
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Sporulation inJournal of fungi (Basel, Switzerland) · 2020Review
- Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity.The Journal of cell biology · 2020Article
- Cellular and metabolic engineering of oleaginous yeastEngineering in life sciences · 2019Review
- Decoupling of Nuclear Division Cycles and Cell Size during the Coenocytic Growth of the Ichthyosporean Sphaeroforma arctica.Current biology : CB · 2018Article
- LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching.The Journal of cell biology · 2018Article
- Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium.Molecular biology of the cell · 2016Article
- Cell-Size Control.Cold Spring Harbor perspectives in biology · 2016Review
- Nuclear autonomy in multinucleate fungi.Current opinion in microbiology · 2015Review
- Life as a moving fluid: fate of cytoplasmic macromolecules in dynamic fungal syncytia.Current opinion in microbiology · 2015Review
- Ploidy variation in multinucleate cells changes under stress.Molecular biology of the cell · 2015Article
- Nuclear repulsion enables division autonomy in a single cytoplasm.Current biology : CB · 2013Article
- Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications.G3 (Bethesda, Md.) · 2013Article
- Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control.Developmental cell · 2013Article
- Cell size control in yeast.Current biology : CB · 2012Article
- Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells.Eukaryotic cell · 2012Article
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5 authors at 1 institution in 2 countries.
Funding
Abstract
Synthesis and accumulation of conserved cell cycle regulators such as cyclins are thought to promote G₁/S and G₂/M transitions in most eukaryotes. When cells at different stages of the cell cycle are fused to form heterokaryons, the shared complement of regulators in the cytoplasm induces the nuclei to become synchronized. However, multinucleate fungi often display asynchronous nuclear division cycles, even though the nuclei inhabit a shared cytoplasm. Similarly, checkpoints can induce nuclear asynchrony in multinucleate cells by arresting only the nucleus that receives damage. The cell biological basis for nuclear autonomy in a common cytoplasm is not known. Here we show that in the filamentous fungus Ashbya gossypii, sister nuclei born from one mitosis immediately lose synchrony in the subsequent G₁ interval. A conserved G₁ transcriptional regulatory circuit involving the Rb-analogue Whi5p promotes the asynchronous behavior yet Whi5 protein is uniformly distributed among nuclei throughout the cell cycle. The homologous Whi5p circuit in S. cerevisiae employs positive feedback to promote robust and coherent entry into the cell cycle. We propose that positive feedback in this same circuit generates timing variability in a multinucleate cell. These unexpected findings indicate that a regulatory program whose products (mRNA transcripts) are translated in a common cytoplasm can nevertheless promote variability in the individual behavior of sister nuclei.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.