ArticleJournal of Alzheimer's disease : JAD2010
Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals.
Article in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 72 citations in OpenAlex.
- Proteomic signatures and mitochondrial dysfunctions in peripheral T cells reveal novel ınsights into Alzheimer's disease.Scientific reports · 2025Article
- Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults.Frontiers in aging neuroscience · 2025Article
- Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Prognosis of Alzheimer's Disease Using Quantitative Mass Spectrometry of Human Blood Plasma Proteins and Machine Learning.International journal of molecular sciences · 2022Article
- Clinically oriented Alzheimer's biosensors: expanding the horizons towards point-of-care diagnostics and beyond.RSC advances · 2021Review
- Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies.Frontiers in aging neuroscience · 2021Article
- Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer's and Parkinson's Diseases.Current neuropharmacology · 2021Review
- Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies.Nature communications · 2020Article
- Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood.Dementia and neurocognitive disorders · 2020Review
- Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- A blood-based signature of cerebrospinal fluid AβScientific reports · 2019Article
- A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.Science advances · 2019Article
- Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- The effect of ApoE ε4 on longitudinal brain region-specific glucose metabolism in patients with mild cognitive impairment: a FDG-PET study.NeuroImage. Clinical · 2019Article
- Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.Molecular psychiatry · 2018Article
- A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations.Journal of Alzheimer's disease : JAD · 2018Review
- A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication.Journal of Alzheimer's disease : JAD · 2018Review
- Plasma lipoproteome in Alzheimer's disease: a proof-of-concept study.Clinical proteomics · 2018Article
- Apolipoproteins and Alzheimer's pathophysiology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
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14 authors at 4 institutions in 2 countries.
Funding
Abstract
Blood-based markers reflecting core pathological features of Alzheimer's disease (AD) in pre-symptomatic individuals are likely to accelerate the development of disease-modifying treatments. Our aim was to discover plasma proteins associated with brain amyloid-β (Aβ) burden in non-demented older individuals. We performed discovery-phase experiments using two dimensional gel electrophoresis (2DGE) and mass spectrometry-based proteomic analysis of plasma in combination with 11C-PiB PET imaging of the brain in samples collected 10 years prior to the PET scans. Confirmatory studies used ELISA assays in a separate set of blood samples obtained within a year of the PET scans. We observed that a panel of 18 2DGE plasma protein spots effectively discriminated between individuals with high and low brain Aβ. Mass spectrometry identified these proteins, many of which have established roles in Aβ clearance, including a strong signal from apolipoprotein-E (ApoE). In validation-phase studies, we observed a strong association between plasma ApoE concentration and Aβ burden in the medial temporal lobe. Targeted voxel-based analysis localized this association to the hippocampus and entorhinal cortex. APOE ε4 carriers also showed greater Aβ levels in several brain regions relative to ε4 non-carriers. These results suggest that both peripheral concentration of ApoE protein and APOE genotype are related to early neuropathological changes in brain regions vulnerable to AD pathology even in the non-demented elderly. Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.