ArticleArteriosclerosis, thrombosis, and vascular biology2010
n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant mice.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Omega-3 Fatty Acids in the Management of Cardiovascular Disease Prevention.Cardiovascular drugs and therapy · 2026Review
- The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection.Biomedicines · 2020Review
- Lipoprotein lipase: new roles for an 'old' enzyme.Current opinion in clinical nutrition and metabolic care · 2019Review
- Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Effect of n-3 Polyunsaturated Fatty Acids on Regression of Coronary Atherosclerosis in Statin Treated Patients Undergoing Percutaneous Coronary Intervention.Korean circulation journal · 2016Article
- Article
- Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis.Current opinion in lipidology · 2013Review
- Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.The Journal of biological chemistry · 2013Article
- Fatty acids regulate endothelial lipase and inflammatory markers in macrophages and in mouse aorta: a role for PPARγ.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- The omega-3 fatty acid nutritional landscape: health benefits and sources.The Journal of nutrition · 2012Review
- n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.Biochimica et biophysica acta · 2011Article
- Inflammation in depression: is adiposity a cause?Dialogues in clinical neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether n-3 fatty acids (n-3) influence arterial cholesterol delivery and lipoprotein lipase (LpL) levels in insulin-resistant mice. METHODS AND
resultsInsulin resistance contributes to risk of cardiovascular disease. It was previously reported that saturated fat (SAT) diets increased, but n-3 diets decreased, arterial low-density lipoprotein (LDL) cholesterol deposition from LDL total and selective uptake; this was associated with increased or decreased arterial LpL, respectively. Insulin receptor transgenic knockout mice (L1) were fed a chow, SAT, or n-3 diet for 12 weeks. Double-fluorescent boron dipyrromethene (BODIPY)-cholesteryl ester (CE) and Alexa dye-labeled human LDL were injected to separately trace LDL-CE and LDL-apolipoprotein B whole particle uptake. In contrast to SAT, n-3 diets markedly reduced all plasma lipids, ameliorating progression of insulin resistance. As opposed to SAT, n-3 reduced arterial LDL uptake, CE deposition, and selective uptake. Disparate patterns of CE deposition between diets were comparable with arterial LpL distribution; SAT induced high LpL levels throughout aortic media; LpL was limited only to intima in n-3-fed mice.
conclusionsn-3 diets diminish arterial LDL-cholesterol deposition in mice with insulin resistance, and this is associated with changes in arterial LpL levels and distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.