Evidence map›Paper›PMID 20930107›Full record

ArticleVeterinary pathology2011

T-lymphocyte predominance in lesions of canine coccidioidomycosis.

L F Shubitz, S M Dial, J N Galgiani

Open access · greenAbstract read
In one paragraph

Article in Veterinary pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

L F ShubitzDepartment of Veterinary Science and Microbiology, 1117 E Lowell St, Room 221, University of Arizona, Tucson, AZ 85721, USA. LFShubit@u.arizona.edu
S M Dial
J N Galgiani
University of Arizona · US

Funding

Validation of Coccidiodes Target Antigens for ImmunotherapyP01AI061310 · NIAID · UNIVERSITY OF ARIZONA · PI DIAL, SHARON M · 2004 to 2008
$4.1M
NIAID NIH HHS P01 AI061310NIAID NIH HHS P01-AI061310-03
6 · The paper itself

Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the southwestern United States. Although cell-mediated immunity is considered critical in control of the infection, little is known of the cellular population in naturally occurring lesions. To characterize the lymphocytic infiltration, archived formalin-fixed, paraffin-embedded tissues (subcutis, pericardium/heart, lung, bone, and synovium) from 18 dogs with coccidioidomycosis were studied with immunohistochemistry for CD3 and CD79a. In nearly all lesions, T lymphocytes were more numerous than B lymphocytes and were distributed throughout the lesion with concentration in the periphery of granulomas, whereas B lymphocytes were mostly confined to the periphery of granulomas. The predominance of T lymphocytes in lesions of canine coccidioidomycosis was independent of the tissue evaluated, the number of intralesional organisms, and the nature or severity of the inflammatory response.

Indexed as

AnimalsCoccidioidesCoccidioidomycosisDog DiseasesDogsGranulomaImmunity, CellularImmunohistochemistryRetrospective StudiesT-Lymphocytes

Identifiers

PMID20930107
PMCPMC7935010
OpenAlexW2117546849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.