Evidence map›Paper›PMID 20929998›Full record

Trial reportDiabetes care2011

Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.

Jordi Salas-Salvadó, Monica Bulló, Nancy Babio, Miguel Ángel Martínez-González, Núria Ibarrola-Jurado, Josep Basora, Ramon Estruch, Maria Isabel Covas, Dolores Corella, Fernando Arós and 3 more

RetractedErratum issued Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT04094194 (Relation of the Nordic Dietary Pattern With Cardiometabolic Risk Factors and Incident Cardiovascular Outcomes), which is not on this map. Cited by 385 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
385citing papers in PubMed, 14 pooled it
34.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04094194 unknown statusnot on this mapstarted 2017, after this paper: background citation

Relation of the Nordic Dietary Pattern With Cardiometabolic Risk Factors and Incident Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials and Prospective Cohort Studies

TypeobservationalSponsorUniversity of TorontoRan2017 to 2019Enrolled1ConditionsBody Weight, Obesity, Overweight and Obesity, Obesity, AbdominalArmsNordic diet
3 · Its place in the literature

Who cites it

385 citing papers in PubMed, 14 syntheses or guidelines pooled it, 889 citations in OpenAlex.

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  7. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
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  10. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
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  12. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
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325 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Jordi Salas-SalvadóHuman Nutrition Unit, Hospital Universitari de Sant Joan, Departament de Bioquímica i Biotecnologia, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain. jordi.salas@urv.cat
Monica Bulló
Nancy Babio
Miguel Ángel Martínez-González
Núria Ibarrola-Jurado
Josep Basora
Ramon Estruch
Maria Isabel Covas
Dolores Corella
Fernando Arós
Valentina Ruiz-Gutiérrez
Emilio Ros
PREDIMED Study Investigators
Instituto de Salud Carlos III · ESInstitut d'Investigació Sanitària Pere Virgili · ESHospital Txagorritxu · ESInstituto de la Grasa · ESUniversidad de Navarra · ESUniversidad Rovira i Virgili · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. RESEARCH DESIGN AND

methodsThis was a three-arm randomized trial in 418 nondiabetic subjects aged 55-80 years recruited in one center (PREDIMED-Reus, northeastern Spain) of the Prevención con Dieta Mediterránea [PREDIMED] study, a large nutrition intervention trial for primary cardiovascular prevention in individuals at high cardiovascular risk. Participants were randomly assigned to education on a low-fat diet (control group) or to one of two MedDiets, supplemented with either free virgin olive oil (1 liter/week) or nuts (30 g/day). Diets were ad libitum, and no advice on physical activity was given. The main outcome was diabetes incidence diagnosed by the 2009 American Diabetes Association criteria.

resultsAfter a median follow-up of 4.0 years, diabetes incidence was 10.1% (95% CI 5.1-15.1), 11.0% (5.9-16.1), and 17.9% (11.4-24.4) in the MedDiet with olive oil group, the MedDiet with nuts group, and the control group, respectively. Multivariable adjusted hazard ratios of diabetes were 0.49 (0.25-0.97) and 0.48 (0.24-0.96) in the MedDiet supplemented with olive oil and nuts groups, respectively, compared with the control group. When the two MedDiet groups were pooled and compared with the control group, diabetes incidence was reduced by 52% (27-86). In all study arms, increased adherence to the MedDiet was inversely associated with diabetes incidence. Diabetes risk reduction occurred in the absence of significant changes in body weight or physical activity.

conclusionsMedDiets without calorie restriction seem to be effective in the prevention of diabetes in subjects at high cardiovascular risk.

Indexed as

Diet, MediterraneanAgedAged, 80 and overCardiovascular DiseasesDiabetes Mellitus, Type 2Dietary SupplementsFemaleHumansMaleMiddle AgedNutsOlive OilPlant OilsRisk FactorsOlive OilPlant Oils

Identifiers

PMID20929998
PMCPMC3005482
OpenAlexW2107073645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.