ArticleScience (New York, N.Y.)2010
A general mechanism for network-dosage compensation in gene circuits.
Article in Science (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 101 citations in OpenAlex.
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during environmental turmoil.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phenotypic selection during laboratory evolution of yeast populations leads to a genome-wide sustainable chromatin compaction shift.Frontiers in microbiology · 2022Article
- Bacteriophage self-counting in the presence of viral replication.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Variation in the modality of a yeast signaling pathway is mediated by a single regulator.eLife · 2021Article
- A synthetic circuit for buffering gene dosage variation between individual mammalian cells.Nature communications · 2021Article
- Decoupling transcription factor expression and activity enables dimmer switch gene regulation.Science (New York, N.Y.) · 2021Article
- Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles.Current genetics · 2021Article
- Synchronization of stochastic expressions drives the clustering of functionally related genes.Science advances · 2019Article
- High-resolution studies of lysis-lysogeny decision-making in bacteriophage lambda.The Journal of biological chemistry · 2019Review
- Article
- Insights into Bidirectional Gene Expression Control Using the Canonical GAL1/GAL10 Promoter.Cell reports · 2018Article
- The Systems Biology of Single-Cell Aging.iScience · 2018Review
- Multi-component gene network design as a survival strategy in diverse environments.BMC systems biology · 2018Article
- Coupling of DNA Replication and Negative Feedback Controls Gene Expression for Cell-Fate Decisions.iScience · 2018Article
- Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mapping the operational landscape of microRNAs in synthetic gene circuits.NPJ systems biology and applications · 2018Article
- Reconciling conflicting models for global control of cell-cycle transcription.Cell cycle (Georgetown, Tex.) · 2017Article
- Noise reduction as an emergent property of single-cell aging.Nature communications · 2017Article
- Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes.PLoS genetics · 2017Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation. By using the yeast galactose network as a model, we combinatorially deleted one of the two copies of its four regulatory genes and found that network activity was robust to the change in network dosage. A mathematical analysis revealed that a two-component genetic circuit with elements of opposite regulatory activity (activator and inhibitor) constitutes a minimal requirement for network-dosage invariance. Specific interaction topologies and a one-to-one interaction stoichiometry between the activating and inhibiting agents were additional essential elements facilitating dosage invariance. This mechanism of network-dosage invariance could represent a general design for gene network structure in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.