ReviewJournal of dental research2011
Fluoride's effects on the formation of teeth and bones, and the influence of genetics.
Review in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A Systematic Review on the Association Between Water Fluoride Levels and Dental Fluorosis: Exploring the 'Halo Effect' and Confounding Environmental Factors.International journal of molecular sciences · 2026Pooled it
- Cardiovascular Health and Fluoride Toxicity: A Qualitative Systematic Review.Cardiovascular toxicology · 2026Pooled it
- Fluoride-Induced Alterations in the Pancreas of Mammals: A Meta-analysis.Biological trace element research · 2025Pooled it
- Pooled it
- Article
- Human Enamel Formation: A Scoping Review for Oral Health Professionals.Dentistry journal · 2026Review
- Ultrastructural alterations of cementum and periodontal ligament in fluorosed teeth: an SEM and EDS study.Odontology · 2026Article
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases.Stem cell reviews and reports · 2026Review
- The associations between plasma fluoride and bone mass in children and adolescents.Pediatric research · 2026Article
- Comparative Evaluation of Anticariogenic Efficacy ofInternational journal of clinical pediatric dentistry · 2026Article
- Assessment of medical and dental students' knowledge, attitudes and practices related to fluoride exposure: a cross-sectional study from Jordan.Frontiers in oral health · 2026Article
- Dental fluorosis in the European roe deer (Capreolus capreolus): A review of the pathological changes in the enamel of fluorotic cheek teeth and the abnormal pattern of dental wear in affected dentitions.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- Quercetin Simultaneously Treats Skeletal Fluorosis and Kashin-Beck Disease by Modulating HIF-1 and Ferroptosis Signaling Pathways.Biological trace element research · 2025Article
- Fluoride induces hepatointestinal damage and vitamin BJournal of advanced research · 2025Article
- Dietary Fluoride Exposure During Early Childhood and Its Association with Dental Fluorosis in a Sample of Mexican Adolescents.International journal of environmental research and public health · 2025Article
- Article
- Design, Synthesis, and Cellular Imaging Application of a Fluorescent Probe Based on Fluoride Ion-Induced Cyclization of Phenothiazine Derivatives.Journal of fluorescence · 2025Article
- Novel mutation inInternational journal of ophthalmology · 2025Article
- MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues.Archives of toxicology · 2024Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. Fluoride's actions on bone cells predominate as anabolic effects both in vitro and in vivo. More recently, fluoride has been shown to induce osteoclastogenesis in mice. Fluorides appear to mediate their actions through the MAPK signaling pathway and can lead to changes in gene expression, cell stress, and cell death. Different strains of inbred mice demonstrate differential physiological responses to ingested fluoride. Genetic studies in mice are capable of identifying and characterizing fluoride-responsive genetic variations. Ultimately, this can lead to the identification of at-risk human populations who are susceptible to the unwanted or potentially adverse effects of fluoride action and to the elucidation of fundamental mechanisms by which fluoride affects biomineralization.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.