ArticleHippocampus2012
The single place fields of CA3 cells: a two-stage transformation from grid cells.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Reproducible and predictable reorganization of place fields driven by grid subfield rate changes.bioRxiv : the preprint server for biology · 2026Article
- Review
- Multi-Scale Extension in an Entorhinal-Hippocampal Model for Cognitive Map Building.Frontiers in neurorobotics · 2020Article
- Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.Hippocampus · 2019Article
- Stable memory and computation in randomly rewiring neural networks.Journal of neurophysiology · 2019Article
- Article
- Article
- From grid cells to place cells with realistic field sizes.PloS one · 2017Article
- Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function.Trends in neurosciences · 2015Review
- Place cell rate remapping by CA3 recurrent collaterals.PLoS computational biology · 2014Article
- New and distinct hippocampal place codes are generated in a new environment during septal inactivation.Neuron · 2014Article
- A signature of attractor dynamics in the CA3 region of the hippocampus.PLoS computational biology · 2014Article
- Spatial scale and place field stability in a grid-to-place cell model of the dorsoventral axis of the hippocampus.Hippocampus · 2013Article
- Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory.Neuromolecular medicine · 2013Article
- Functional circuits of new neurons in the dentate gyrus.Frontiers in neural circuits · 2013Review
- A goal-directed spatial navigation model using forward trajectory planning based on grid cells.The European journal of neuroscience · 2012Article
- The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus.Scientific reports · 2012Article
- Selective reduction of AMPA currents onto hippocampal interneurons impairs network oscillatory activity.PloS one · 2012Article
- Ensemble place codes in hippocampus: CA1, CA3, and dentate gyrus place cells have multiple place fields in large environments.PloS one · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Granule cells of the dentate gyrus (DG) generally have multiple place fields, whereas CA3 cells, which are second order, have only a single place field. Here, we explore the mechanisms by which the high selectivity of CA3 cells is achieved. Previous work showed that the multiple place fields of DG neurons could be quantitatively accounted for by a model based on the number and strength of grid cell inputs and a competitive network interaction in the DG that is mediated by gamma frequency feedback inhibition. We have now built a model of CA3 based on similar principles. CA3 cells receive input from an average of one active DG cell and from 1,400 cortical grid cells. Based on experimental findings, we have assumed a linear interaction of the two pathways. The results show that simulated CA3 cells generally have a single place field, as observed experimentally. Thus, a two-step process based on simple rules (and that can occur without learning) is able to explain how grid cell inputs to the hippocampus give rise to cells having ultimate spatial selectivity. The CA3 processes that produce a single place depend critically on the competitive network processes and do not require the direct cortical inputs to CA3, which are therefore likely to perform some other unknown function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.