SynthesisThe Cochrane database of systematic reviews2010
Different classes of antibiotics given to women routinely for preventing infection at caesarean section.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Different classes of antibiotics given to women routinely for preventing infection at caesarean section.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section.The Cochrane database of systematic reviews · 2016Pooled it
- Different classes of antibiotics given to women routinely for preventing infection at caesarean section.The Cochrane database of systematic reviews · 2014Pooled it
- Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section.The Cochrane database of systematic reviews · 2014Pooled it
- Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infections.BMC pregnancy and childbirth · 2015Trial
- Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital.PloS one · 2017Article
- Post partum infections: A review for the non-OBGYN.Obstetric medicine · 2014Article
- Hospital and provider patient volumes, cesarean section rates, and early postpartum invasive methicillin-resistant Staphylococcus aureus infection.American journal of infection control · 2014Article
- Controversies in obstetric anesthesia.Journal of anesthesia · 2013Review
- [Anesthesiological management of Caesarean sections : nationwide survey in Germany].Der Anaesthesist · 2011Review
- Reproductive health and the industrialized food system: a point of intervention for health policy.Health affairs (Project Hope) · 2011Article
Corrections and comments
- Updated by
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaesarean section increases the risk of postpartum infection for women and prophylactic antibiotics have been shown to reduce the incidence; however, there are adverse effects. It is important to identify the most effective class of antibiotics to use and those with the least adverse effects.
objectivesTo determine, from the best available evidence, the balance of benefits and harms between different classes of antibiotic given prophylactically to women undergoing caesarean section. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (April 2010) and reference lists of retrieved papers. SELECTION CRITERIA: We included randomised controlled trials comparing different classes of prophylactic antibiotics given to women undergoing caesarean section. We excluded trials that compared drugs with placebo or drugs within a specific class; these are assessed in other Cochrane Reviews. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed the studies for inclusion, assessed risk of bias and carried out data extraction. MAIN
resultsWe included 29 studies of which 25 provided data on 6367 women. There was a lack of good quality data and important outcomes often included only small numbers of women. This meant we could only conclude that the current evidence shows no overall difference between the different classes of antibiotics in terms of reducing maternal infections after caesarean sections. However, none of the studies looked at outcomes on the baby, nor did they report infections diagnosed after the initial postoperative hospital stay. We were unable to assess what impact, if any, the use of different classes of antibiotics might have on bacterial resistance. AUTHORS'
conclusionsBased on the best currently available evidence, cephalosporins and penicillins have similar efficacy at caesarean section when considering immediate postoperative infections. We have no data for outcomes on the baby, nor on late infections (up to 30 days) in the mother. Clinicians need to consider bacterial resistance and women's individual circumstances.
Indexed as
Identifiers
20927776What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.