ArticleJournal of neuro-oncology2011
Stripe-like increase of rCBV beyond the visible border of glioblastomas: site of tumor infiltration growing after neurosurgery.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- The Invasive Margin of Glioblastoma as a Molecular Ecosystem: Spatial Heterogeneity, Tumor-Host Interactions, and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Exploring the Role of Advanced MRI in Understanding Glioblastoma Biology: A Scoping Review.Cancers · 2026Review
- Magnetic resonance imaging-guided linear accelerator arterial spin labelling reveals dynamics of highly perfused non-enhancing glioblastoma during radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Malignant Cells Beyond the Tumor Core: The Non-Negligible Factor to Overcome the Refractory of Glioblastoma.CNS neuroscience & therapeutics · 2025Review
- Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.Nature communications · 2024Article
- The potential of advanced MR techniques for precision radiotherapy of glioblastoma.Magma (New York, N.Y.) · 2022Review
- DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study.Clinical neuroradiology · 2021Article
- Multimodal MRI characteristics of the glioblastoma infiltration beyond contrast enhancement.Therapeutic advances in neurological disorders · 2019Article
- Post-operative perfusion and diffusion MR imaging and tumor progression in high-grade gliomas.PloS one · 2019Article
- Comparison ofEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma.European radiology · 2017Article
- Quantitative T1-mapping detects cloudy-enhancing tumor compartments predicting outcome of patients with glioblastoma.Cancer medicine · 2017Observational
- Amino acid PET and MR perfusion imaging in brain tumours.Clinical and translational imaging · 2017Review
- Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors.Radiation oncology (London, England) · 2016Review
- Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.Journal of magnetic resonance imaging : JMRI · 2016Article
- Assessing and monitoring intratumor heterogeneity in glioblastoma: how far has multimodal imaging come?CNS oncology · 2015Review
- Article
- Survival analysis in patients with newly diagnosed primary glioblastoma multiforme using pre- and post-treatment peritumoral perfusion imaging parameters.Journal of neuro-oncology · 2014Article
- Facing contrast-enhancing gliomas: perfusion MRI in grade III and grade IV gliomas according to tumor area.BioMed research international · 2014Article
- MR perfusion in and around the contrast-enhancement of primary CNS lymphomas.Journal of neuro-oncology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We observed a stripe-like pattern of regional cerebral blood volume (rCBV) increase in a defined region adjacent to the contrast enhancement (CE) on MRI of glioblastomas (GBM) that we defined as the "striate sign" (SS). We hypothesized that the SS marks infiltration of GBM outside the CE volume transforming into future CE tumor in the follow-up. T2*-weighted dynamic susceptibility-weighted CE (DSC)-MRI, and T1 and T2-weighted images (WI) of 16 patients with GBM were retrospectively evaluated in a baseline MRI performed before neurosurgery. In seven of these patients we also performed a (1)H MR spectroscopic imaging ((1)H MRSI). The regions of interest (ROI) delineating the SS were defined on rCBV maps for each patient. ROIs were overlaid on follow-up T1-WI and T2-WI MRI performed 3, 6, and 9 months after neurosurgery. Size and maximum signal intensity (max SI) of de novo CE within the area of the SS were analyzed. Statistical analysis was performed with the Friedman test (P < 0.05). In 15/16 patients de novo CE completely covered the area of the SS within nine months. Normalized max SI of de-novo CE of the 3, 6, and 9-months follow-up MR examinations were significantly higher than in the baseline MRI (P < 0.001). Normalized choline was increased within the SS in all patients with de novo CE (n = 6). De-novo CE appeared within the SS in all patients (96% of all slices). This implies that the SS might indicate the site of future CE tumor, which represents the area of tumor growth after neurosurgery.
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