ReviewCellular and molecular life sciences : CMLS2011
The gap gene network.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 1 synthesis or guideline pooled it, 309 citations in OpenAlex.
- A systematic review on the effects of acrylamide and bisphenol A on the development of Drosophila melanogaster.Molecular biology reports · 2022Pooled it
- Genetic and Molecular Regulation of Ecdysone Biosynthesis During Insect Metamorphosis.Insects · 2026Review
- Asymmetric chromatin accessibility underlies anterior-posterior axis specification in moth fly embryos.PLoS biology · 2026Article
- Maternal patterning in early Drosophila embryos: how much information can single maternal gradients supply?Development (Cambridge, England) · 2026Article
- Rapid transcriptional response to a dynamic morphogen by time integration.Current biology : CB · 2026Article
- Gene regulatory networks: from correlative models to causal explanations.Nature reviews. Genetics · 2026Review
- Developmental patterning of adipose tissue bybioRxiv : the preprint server for biology · 2026Article
- The Dynamics of Inducible Genetic Circuits.ArXiv · 2026Article
- Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025Article
- Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos.Nature communications · 2025Article
- Optimization and variability can coexist.ArXiv · 2025Article
- Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis.Nature communications · 2025Article
- Beyond the heat shock pathway: Heat stress responses in Drosophila development.Developmental biology · 2025Review
- Deriving a genetic regulatory network from an optimization principle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcription factor clusters as information transfer agents.Science advances · 2025Article
- Stable developmental patterns of gene expression without morphogen gradients.PLoS computational biology · 2024Article
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Understanding developmental system drift.Development (Cambridge, England) · 2024Review
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap genes are involved in segment determination during the early development of the fruit fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize the current knowledge of the gap gene network through a comprehensive survey of the experimental literature. I focus on genetic and molecular evidence, which provides us with an almost-complete picture of the regulatory interactions responsible for trunk gap gene expression. I discuss the regulatory mechanisms involved, and highlight the remaining ambiguities and gaps in the evidence. This is followed by a brief discussion of molecular regulatory mechanisms for transcriptional regulation, as well as precision and size-regulation provided by the system. Finally, I discuss evidence on the evolution of gap gene expression from species other than Drosophila. My survey concludes that studies of the gap gene system continue to reveal interesting and important new insights into the role of gene regulatory networks in development and evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.