ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2011
Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogens.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Current View on Major Natural Compounds Endowed with Antibacterial and Antiviral Effects.Antibiotics (Basel, Switzerland) · 2024Review
- Beyond the Risk of Biofilms: An Up-and-Coming Battleground of Bacterial Life and Potential Antibiofilm Agents.Life (Basel, Switzerland) · 2023Review
- Individual and social defenses inFrontiers in physiology · 2023Review
- Enhanced Bioactivity of Tailor-Made Glycolipid Enriched Manuka Honey.International journal of molecular sciences · 2022Article
- Factors affecting the production and measurement of hydrogen peroxide in honey samples.Access microbiology · 2021Article
- Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?Antibiotics (Basel, Switzerland) · 2020Review
- Effects of phenolic and protein extracts fromFood science and biotechnology · 2020Article
- Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria.Molecules (Basel, Switzerland) · 2020Article
- Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature.Clinical, cosmetic and investigational dermatology · 2020Review
- Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa.Scientific reports · 2019Article
- In vitro evaluation of methicillin-resistant and methicillin-sensitive Staphylococcus aureus susceptibility to Saudi honeys.BMC complementary and alternative medicine · 2019Article
- Antibacterial Activity of Honey against Methicillin-ResistantInternational journal of microbiology · 2019Article
- A cost-effective colourimetric assay for quantifying hydrogen peroxide in honey.Access microbiology · 2019Article
- Impact of honey on dental erosion and adhesion of early bacterial colonizers.Scientific reports · 2018Article
- Honey: Single food stuff comprises many drugs.Saudi journal of biological sciences · 2018Review
- The Antibacterial EffectDermatology research and practice · 2018Article
- Characterization and Classification of Iranian Honey Based on Physicochemical Properties and Antioxidant Activities, with Chemometrics Approach.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Traditional Therapies for Skin Wound Healing.Advances in wound care · 2016Review
- The Antibacterial Activity of Australian Leptospermum Honey Correlates with Methylglyoxal Levels.PloS one · 2016Article
- Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals.Biological research · 2015Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honey has potent activity against both antibiotic-sensitive and -resistant bacteria, and is an interesting agent for topical antimicrobial application to wounds. As honey is diluted by wound exudate, rapid bactericidal activity up to high dilution is a prerequisite for its successful application. We investigated the kinetics of the killing of antibiotic-resistant bacteria by RS honey, the source for the production of Revamil® medical-grade honey, and we aimed to enhance the rapid bactericidal activity of RS honey by enrichment with its endogenous compounds or the addition of antimicrobial peptides (AMPs). RS honey killed antibiotic-resistant isolates of Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus faecium, and Burkholderia cepacia within 2 h, but lacked such rapid activity against methicillin-resistant S. aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. It was not feasible to enhance the rapid activity of RS honey by enrichment with endogenous compounds, but RS honey enriched with 75 μM of the synthetic peptide Bactericidal Peptide 2 (BP2) showed rapid bactericidal activity against all species tested, including MRSA and ESBL E. coli, at up to 10-20-fold dilution. RS honey enriched with BP2 rapidly killed all bacteria tested and had a broader spectrum of bactericidal activity than either BP2 or honey alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.