ArticleChromosoma2011
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis.
Article in Chromosoma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Telomeres in mitosis: organization and dynamics.Nucleus (Austin, Tex.) · 2026Review
- Meiotic telomeres of vole B chromosomes: shelterin and associated proteins provide a link to the nuclear envelope.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Review
- Article
- Nuclear envelope tethering inhibits the formation of ALT-associated PML bodies in ALT cells.Aging · 2021Article
- Sexual Dimorphism in Mouse Meiosis.Frontiers in cell and developmental biology · 2021Review
- Interplay of the nuclear envelope with chromatin in physiology and pathology.Nucleus (Austin, Tex.) · 2020Review
- FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.Nucleic acids research · 2019Article
- Article
- Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.Journal of virology · 2017Article
- Finding a place in the SUN: telomere maintenance in a diverse nuclear landscape.Current opinion in cell biology · 2016Review
- Article
- TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.Cell reports · 2014Article
- Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.BMC cell biology · 2014Article
- The Chromosomal Courtship Dance-homolog pairing in early meiosis.Current opinion in cell biology · 2014Review
- The meiosis-specific modification of mammalian telomeres.Cell cycle (Georgetown, Tex.) · 2014Review
- Ku70 and non-homologous end joining protect testicular cells from DNA damage.Journal of cell science · 2013Article
- One identity or more for telomeres?Frontiers in oncology · 2013Article
- Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.Cell reports · 2012Article
- Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Attachment of telomeres to the nuclear envelope (NE) and their clustering in a chromosomal bouquet during meiotic prophase I is an evolutionary conserved event that promotes chromosome pairing and recombination. In fission yeast, bouquet formation fails when the telomeric protein Rap1 is absent or when the telomeric protein Taz1 fails to recruit Rap1 to telomeres. The mammalian Rap1 orthologue is a component of the shelterin complex and localises to telomeres through an interaction with a Taz1-like telomeric DNA binding factor, TRF2. Here, we investigated the role of mammalian Rap1 in meiotic telomere attachment and clustering by analysing spermatogenesis in Rap1-deficient mice. The results establish that the meiotic three-dimensional nuclear architecture and recombination are not affected by the absence of Rap1. Furthermore, Rap1-deficient meiotic telomeres assemble the SUN1 nuclear membrane protein, attach to the NE, and undergo bouquet formation indistinguishable from the wild-type setting. Thus, the role of Rap1 in meiosis is not conserved between fission yeast and mammals, suggesting that mammals have alternative modes for connecting telomeres to SUN proteins on the meiotic nuclear envelope.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.