Evidence map›Paper›PMID 20927439›Full record

ArticleChemical communications (Cambridge, England)2010

Identification of epigenetic DNA modifications with a protein nanopore.

Emma V B Wallace, David Stoddart, Andrew J Heron, Ellina Mikhailova, Giovanni Maglia, Timothy J Donohoe, Hagan Bayley

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Article
  2. A pentose, as a cytosine nucleobase modification inApplied and environmental microbiology · 2026
    Article
  3. Review
  4. Review
  5. Role of epigenetics in OSCC: an understanding above genetics.Medical oncology (Northwood, London, England) · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Nanopore sensing: A physical-chemical approach.Biochimica et biophysica acta. Biomembranes · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. DNAmod: the DNA modification database.Journal of cheminformatics · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma V B WallaceDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA.
David Stoddart
Andrew J Heron
Ellina Mikhailova
Giovanni Maglia
Timothy J Donohoe
Hagan Bayley

Funding

Single-Molecule DNA Sequencing with Engineered NanoporesR01HG003709 · NHGRI · SCRIPPS RESEARCH INSTITUTE, THE · PI GHADIRI, M. REZA · 2005 to 2017
$13.2M
Biotechnology and Biological Sciences Research CouncilNHGRI NIH HHS R01 HG003709
6 · The paper itself

Abstract

Two DNA bases, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (hmC), marks of epigenetic modification, are recognized in immobilized DNA strands and distinguished from G, A, T and C by nanopore current recording. Therefore, if further aspects of nanopore sequencing can be addressed, the approach will provide a means to locate epigenetic modifications in unamplified genomic DNA.

Indexed as

Nanopores5-MethylcytosineCyclodextrinsCytosineDNAEpigenesis, GeneticHemolysin Proteins5-hydroxymethylcytosine5-MethylcytosineCyclodextrinsCytosineDNAHemolysin Proteins

Identifiers

PMID20927439
PMCPMC3147113

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.