ArticlePLoS biology2010
Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Braking Parkinson's progression: the hypothetical druggable role of striatal parvalbumin interneurons.NPJ Parkinson's disease · 2026Review
- Functional Autapses Selectively Form in a Subpopulation of Subicular Pyramidal Cells in Hippocampal Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice.Nature communications · 2025Article
- Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.Cell reports · 2024Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.bioRxiv : the preprint server for biology · 2024Article
- Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release.eLife · 2024Article
- Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder.Brain sciences · 2023Article
- Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons.Neuroscience bulletin · 2023Article
- Behavioral regulation by perineuronal nets in the prefrontal cortex of the CNTNAP2 mouse model of autism spectrum disorder.Frontiers in behavioral neuroscience · 2023Article
- Article
- Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons.Cell reports · 2022Article
- Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus.Nature communications · 2022Article
- Synaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia.The American journal of psychiatry · 2022Article
- Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.Frontiers in molecular neuroscience · 2022Article
- Distinct Laminar and Cellular Patterns of GABA Neuron Transcript Expression in Monkey Prefrontal and Visual Cortices.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses.Cell reports · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Networks of specific inhibitory interneurons regulate principal cell firing in several forms of neocortical activity. Fast-spiking (FS) interneurons are potently self-inhibited by GABAergic autaptic transmission, allowing them to precisely control their own firing dynamics and timing. Here we show that in FS interneurons, high-frequency trains of action potentials can generate a delayed and prolonged GABAergic self-inhibition due to sustained asynchronous release at FS-cell autapses. Asynchronous release of GABA is simultaneously recorded in connected pyramidal (P) neurons. Asynchronous and synchronous autaptic release show differential presynaptic Ca(2+) sensitivity, suggesting that they rely on different Ca(2+) sensors and/or involve distinct pools of vesicles. In addition, asynchronous release is modulated by the endogenous Ca(2+) buffer parvalbumin. Functionally, asynchronous release decreases FS-cell spike reliability and reduces the ability of P neurons to integrate incoming stimuli into precise firing. Since each FS cell contacts many P neurons, asynchronous release from a single interneuron may desynchronize a large portion of the local network and disrupt cortical information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.