ArticlePloS one2010
Land use, macroalgae, and a tumor-forming disease in marine turtles.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 134 citations in OpenAlex.
- Assessment of Exposure to Essential and Non-Essential Elements through Concentrations in Tissues of Chelonia mydas (Green turtles) from the South Atlantic, Northeast Brazil.Biological trace element research · 2026Article
- Physiological responses and adaptive mechanisms of amphibians and reptiles to multiple interacting environmental stressors: an integrative review.Frontiers in physiology · 2026Review
- Disorders of the Female Reproductive Tract in Chelonians: A Review.Animals : an open access journal from MDPI · 2025Review
- Fibropapillomatosis Dynamics, Severity and Demographic Effect in Caribbean Green Turtles.EcoHealth · 2025Article
- Fibropapillomatosis: A Review of the Disease with Attention to the Situation Northern Coast of Brazil.Animals : an open access journal from MDPI · 2024Review
- Green Turtle Fibropapillomatosis: Tumor Morphology and Growth Rate in a Rehabilitation Setting.Veterinary sciences · 2023Article
- Article
- Symblepharon, Ankyloblepharon, and Salt Gland Dysfunction in a Loggerhead Sea Turtle (Veterinary sciences · 2022Article
- Sea Turtles in the Cancer Risk Landscape: A Global Meta-Analysis of Fibropapillomatosis Prevalence and Associated Risk Factors.Pathogens (Basel, Switzerland) · 2021Article
- Evolutionary Comparisons of Chelonid Alphaherpesvirus 5 (ChHV5) Genomes from Fibropapillomatosis-Afflicted Green (Animals : an open access journal from MDPI · 2021Article
- Fibropapillomatosis and the Chelonid Alphaherpesvirus 5 in Green Turtles from West Africa.EcoHealth · 2021Article
- Chelonid Alphaherpesvirus 5 Prevalence and First Confirmed Case of Sea Turtle Fibropapillomatosis in Grenada, West Indies.Animals : an open access journal from MDPI · 2021Article
- Environmental DNA monitoring of oncogenic viral shedding and genomic profiling of sea turtle fibropapillomatosis reveals unusual viral dynamics.Communications biology · 2021Article
- Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors.Communications biology · 2021Article
- Article
- Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma.Wellcome open research · 2021Article
- Herpesviruses in Reptiles.Frontiers in veterinary science · 2021Review
- Herbaria macroalgae as a proxy for historical upwelling trends in Central California.Proceedings. Biological sciences · 2020Article
- Harmful algal and cyanobacterial toxins in foraging green turtles (Toxicon: X · 2020Article
- Disease risk analysis in sea turtles: A baseline study to inform conservation efforts.PloS one · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wildlife diseases are an increasing concern for endangered species conservation, but their occurrence, causes, and human influences are often unknown. We analyzed 3,939 records of stranded Hawaiian green sea turtles (Chelonia mydas) over 28 years to understand fibropapillomatosis, a tumor-forming disease linked to a herpesvirus. Turtle size is a consistent risk factor and size-standardized models revealed considerable spatial and temporal variability. The disease peaked in some areas in the 1990s, in some regions rates remained constant, and elsewhere rates increased. Land use, onshore of where the turtles feed, may play a role. Elevated disease rates were clustered in watersheds with high nitrogen-footprints; an index of natural and anthropogenic factors that affect coastal eutrophication. Further analysis shows strong epidemiological links between disease rates, nitrogen-footprints, and invasive macroalgae and points to foraging ecology. These turtles now forage on invasive macroalgae, which can dominate nutrient rich waters and sequester environmental N in the amino acid arginine. Arginine is known to regulate immune activity, promote herpesviruses, and contribute to tumor formation. Our results have implications for understanding diseases in aquatic organisms, eutrophication, herpesviruses, and tumor formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.