ArticlePLoS biology2010
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
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- Development of a Specific PCR Assay forPathogens (Basel, Switzerland) · 2024Article
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- Isolation and propagation of an Egyptian Theileria annulata infected cell line and evaluation of its use as a vaccine to protect cattle against field challenge.Scientific reports · 2024Article
- Toxoplasma gondii modulates the host cell cycle, chromosome segregation, and cytokinesis irrespective of cell type or species origin.Parasites & vectors · 2024Article
- Epidemiological situation of bovine tropical theileriosis in an arid region in central Tunisia with a phylogenetic analysis of Theileria annulata.Veterinary medicine and science · 2023Article
- Exploring the Transcriptome Dynamics of In VivoGenes · 2023Article
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- Genetic Resistance of Bovines to Theileriosis.Animals : an open access journal from MDPI · 2022Review
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- Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity.PLoS neglected tropical diseases · 2020Article
- Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review.Pathogens (Basel, Switzerland) · 2020Review
- Besnoitia besnoiti-driven endothelial host cell cycle alteration.Parasitology research · 2020Article
- Theileria parva: a parasite of African buffalo, which has adapted to infect and undergo transmission in cattle.International journal for parasitology · 2020Review
- Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation.Scientific reports · 2020Article
- Article
- Molecular Dissection of the Antibody Response: Opportunities and Needs for Application in Cattle.Frontiers in immunology · 2020Review
- Mutations in the TaPIN1 peptidyl prolyl isomerase gene in Theileria annulata parasites isolated in Sudan.International journal for parasitology. Drugs and drug resistance · 2019Article
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6 authors at 2 institutions in 2 countries.
Funding
Abstract
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host cell cytoplasm and is strictly intracellular. To maintain transformation, it is crucial that this syncytium is divided over the two daughter cells at each host cell cytokinesis. This process was dissected using different cell cycle synchronization methods in combination with the targeted application of specific inhibitors. We found that Theileria schizonts associate with newly formed host cell microtubules that emanate from the spindle poles, positioning the parasite at the equatorial region of the mitotic cell where host cell chromosomes assemble during metaphase. During anaphase, the schizont interacts closely with host cell central spindle. As part of this process, the schizont recruits a host cell mitotic kinase, Polo-like kinase 1, and we established that parasite association with host cell central spindles requires Polo-like kinase 1 catalytic activity. Blocking the interaction between the schizont and astral as well as central spindle microtubules prevented parasite segregation between the daughter cells during cytokinesis. Our findings provide a striking example of how an intracellular eukaryotic pathogen that evolved ways to induce the uncontrolled proliferation of the cells it infects usurps the host cell mitotic machinery, including Polo-like kinase 1, one of the pivotal mitotic kinases, to ensure its own persistence and survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.