ArticlePloS one2010
Age-correlated gene expression in normal and neurodegenerative human brain tissues.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Convergence of Accelerated Brain Volume Decline in Normal Aging and Alzheimer's Disease Pathology.Journal of Alzheimer's disease : JAD · 2024Article
- MicroRNAs as Candidate Biomarkers for Alzheimer's Disease.Non-coding RNA · 2021Review
- Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- The self-organization model reveals systematic characteristics of aging.Theoretical biology & medical modelling · 2020Article
- Rate of brain aging andLife science alliance · 2019Article
- MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging.Nature communications · 2018Article
- Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline.Frontiers in genetics · 2018Article
- Integrative analysis of methylation and transcriptional profiles to predict aging and construct aging specific cross-tissue networks.BMC systems biology · 2016Article
- A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine.Journal of molecular neuroscience : MN · 2015Article
- Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.Molecular systems biology · 2014Article
- Chaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasome.Biomolecules · 2014Review
- Rare Variants and Transcriptomics in Alzheimer disease.Current genetic medicine reports · 2014Article
- Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects.Frontiers in aging neuroscience · 2014Article
- Distinctive topology of age-associated epigenetic drift in the human interactome.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting.Molecular biology of the cell · 2013Article
- RNA-Seq and human complex diseases: recent accomplishments and future perspectives.European journal of human genetics : EJHG · 2013Review
- Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains.PloS one · 2013Article
- BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease.PloS one · 2013Article
- An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHuman brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles. PRINCIPAL
findingsWe have developed a computational method for assessing an individual's "physiological brain age" by comparing global mRNA expression datasets across a range of normal human brain samples. Application of this method to brains samples from select regions in two diseases--Alzheimer's disease (AD, superior frontal gyrus), frontotemporal lobar degeneration (FTLD, in rostral aspect of frontal cortex ∼BA10)--showed that while control cohorts exhibited no significant difference between physiological and chronological ages, FTLD and AD exhibited prematurely aged expression profiles.
conclusionsThis study establishes a quantitative scale for measuring premature aging in neurodegenerative disease cohorts, and it identifies specific physiological mechanisms common to aging and some forms of neurodegeneration. In addition, accelerated expression profiles associated with AD and FTLD suggest some common mechanisms underlying the risk of developing these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.