ArticleIndian journal of pharmacology2010
Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease.
Article in Indian journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Article
- Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects.BMC complementary and alternative medicine · 2016Article
- Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats.BMC complementary and alternative medicine · 2014Article
- Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease.Molecules (Basel, Switzerland) · 2013Review
- Wound-healing activity of ethanolic and aqueous extracts of Ficus benghalensis.Journal of advanced pharmaceutical technology & research · 2011Article
- Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study was designed to evaluate the effects of ethanol extract of Ficus bengalensis Linn. bark (AEFB) on inflammatory bowel disease (IBD). MATERIALS AND
methodsEffects of AEFB were studied on 2,4,6-trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on first day only) induced IBD in rats. The effects of co-administration of prednisolone (2 mg/kg) and AEFB (250, 500 mg/kg) for 21 days were evaluated. Animals sacrificed at end of the experiment and various histopathological parameters like colon mucosal damage index (CMDI) and disease activity index (DAI) were assessed. In the colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and nitric oxide (NO) levels and in mesentery % mast cell protection was also measured.
resultsRats treated with only TNBS showed more score of CMDI and DAI, higher MDA, NO, MPO, and lower SOD activity as compared to the control group. Treatment with AEFB significantly declined both indices scores and decreased the MPO, MDA, NO, and increased the SOD activity. AEFB also increased the % mast cell protection compared to alone TNBS-treated animals.
conclusionIn our study, we found that AEFB has a significant protective effect in the IBD in rats that is comparable to that of prednisolone and may be because of the presence of flavonoids, terpenoids, and phenolic compounds.
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