ArticleJournal of immunology (Baltimore, Md. : 1950)2010
A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Liver-draining portal lymph node responds to enteric nematode infection by generating highly parasite-specific follicular T helper and B cell responses.Frontiers in immunology · 2025Article
- HSV-1 0∆NLS vaccine elicits a robust B lymphocyte response and preserves vision without HSV-1 glycoprotein M or thymidine kinase recognition.Scientific reports · 2022Article
- Trickle infection withFrontiers in immunology · 2022Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Regulation of the germinal center and humoral immunity by interleukin-21.The Journal of experimental medicine · 2020Review
- Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases.Frontiers in cellular and infection microbiology · 2019Review
- Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver.Frontiers in physiology · 2018Article
- Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity.Mucosal immunology · 2017Review
- Article
- IL-21 and T Cell Differentiation: Consider the Context.Trends in immunology · 2016Review
- Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids.The Journal of infectious diseases · 2016Article
- Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products.Journal of visualized experiments : JoVE · 2015Article
- Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria.PLoS pathogens · 2015Article
- Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Interleukin-21: a double-edged sword with therapeutic potential.Nature reviews. Drug discovery · 2014Review
- Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.Frontiers in immunology · 2014Review
- The unique features of follicular T cell subsets.Cellular and molecular life sciences : CMLS · 2013Review
- IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.Journal of neuroimmunology · 2013Article
- IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.European journal of immunology · 2013Article
- Investigating the role for IL-21 in rabies virus vaccine-induced immunity.PLoS neglected tropical diseases · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pathogen-specific Ab production following infection with the gut-dwelling roundworm Heligmosomoides polygyrus is critical for protective immunity against reinfection. However, the factors required for productive T cell-B cell interactions in the context of a type 2-dominated immune response are not well defined. In the present study, we identify IL-21R signaling as a critical factor in driving pathogen-specific plasma cell differentiation and protective immunity against H. polygyrus in mice. We show that B cells require direct IL-21R signals to differentiate into CD138(+) plasma cells. In contrast, IL-21R signaling is dispensable for germinal center formation, isotype class switching, and Th2 and T follicular helper cell differentiation. Our studies demonstrate a selective role for IL-21 in plasma cell differentiation in the context of protective antiparasitic type 2 immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.