ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Effect of intracerebroventricular benzamil on cardiovascular and central autonomic responses to DOCA-salt treatment.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Role of the median preoptic nucleus in the development of chronic deoxycorticosterone acetate (DOCA)-salt hypertension.Physiological reports · 2024Article
- Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis.Clinical and experimental pharmacology & physiology · 2021Article
- Cardiac Natriuretic Peptide Profiles in Chronic Hypertension by Single or Sequentially Combined Renovascular and DOCA-Salt Treatments.Frontiers in physiology · 2021Article
- Lesion of the OVLT markedly attenuates chronic DOCA-salt hypertension in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Elevated Oxidative Stress and Inflammation in Hypothalamic Paraventricular Nucleus Are Associated With Sympathetic Excitation and Hypertension in Rats Exposed to Chronic Intermittent Hypoxia.Frontiers in physiology · 2018Article
- DOCA-Salt Hypertension: an Update.Current hypertension reports · 2017Review
- Review
- The multifaceted mineralocorticoid receptor.Comprehensive Physiology · 2014Review
- The neurogenic phase of angiotensin II-salt hypertension is prevented by chronic intracerebroventricular administration of benzamil.Physiological reports · 2014Article
- Neurogenic and sympathoexcitatory actions of NaCl in hypertension.Current hypertension reports · 2013Review
- ENaC-expressing neurons in the sensory circumventricular organs become c-Fos activated following systemic sodium changes.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats.American journal of physiology. Heart and circulatory physiology · 2013Article
- Central neuromodulatory pathways regulating sympathetic activity in hypertension.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
- How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.American journal of physiology. Heart and circulatory physiology · 2012Review
- Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.American journal of physiology. Endocrinology and metabolism · 2012Article
- The role of the subfornical organ in angiotensin II-salt hypertension in the rat.Experimental physiology · 2012Article
- Role of spinal V1a receptors in regulation of arterial pressure during acute and chronic osmotic stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
DOCA-salt treatment increases mean arterial pressure (MAP), while central infusion of benzamil attenuates this effect. The present study used c-Fos immunoreactivity to assess the role of benzamil-sensitive proteins in the brain on neural activity following chronic DOCA-salt treatment. Uninephrectomized rats were instrumented with telemetry transmitters for measurement of MAP and with an intracerebroventricular (ICV) cannula for benzamil administration. Groups included rats receiving DOCA-salt treatment alone, rats receiving DOCA-salt treatment with ICV benzamil, and appropriate controls. At study completion, MAP in vehicle-treated DOCA-salt rats reached 142 ± 4 mmHg. In contrast DOCA-salt rats receiving ICV benzamil had lower MAP (124 ± 3 mmHg). MAP in normotensive controls was 102 ± 3 mmHg. c-Fos immunoreactivity was quantified in the supraoptic nucleus (SON) and across subnuclei of the hypothalamic paraventricular nucleus (PVN), as well as other cardiovascular regulatory sites. Compared with vehicle-treated normotensive controls, c-Fos expression was increased in the SON and all subnuclei of the PVN, but not in other key autonomic nuclei, such as the rostroventrolateral medulla. Moreover, benzamil treatment decreased c-Fos immunoreactivity in the SON and in medial parvocellular and posterior magnocellular neurons of the PVN in DOCA-salt rats but not areas associated with regulation of sympathetic activity. Our results do not support the hypothesis that DOCA-salt increases neuronal activity (as indicated by c-Fos immunoreactivity) of other key regions that regulate sympathetic activity. These results suggest that ICV benzamil attenuates DOCA-salt hypertension by modulation of neuroendocrine-related PVN nuclei rather than inhibition of PVN sympathetic premotor neurons in the PVN and rostroventrolateral medulla.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.