ArticleClinical and vaccine immunology : CVI2011
Development and characterization of protective Haemophilus parasuis subunit vaccines based on native proteins with affinity to porcine transferrin and comparison with other subunit and commercial vaccines.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Temporal Dynamics of T Cell Immunity Induced by TbpBVeterinary sciences · 2026Article
- Design of B-Cell Multi-Epitope Subunit Vaccines AgainstTransboundary and emerging diseases · 2026Article
- TbpB-based oral mucosal vaccine provides heterologous protection against Glässer's disease caused by different serovars of Spanish field isolates of Glaesserella parasuis.Porcine health management · 2024Article
- Screening of linear B-cell epitopes and its proinflammatory activities ofFrontiers in cellular and infection microbiology · 2023Article
- TbpBPathogens (Basel, Switzerland) · 2022Article
- New Pathological Lesions Developed in Pigs by a "Non-virulent" Strain ofFrontiers in veterinary science · 2020Article
- Proof of Concept for Prevention of Natural Colonization by Oral Needle-Free Administration of a Microparticle Vaccine.Frontiers in immunology · 2020Article
- Transcriptomics of Haemophilus (Glässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens.BMC veterinary research · 2018Article
- The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity.Scientific reports · 2018Article
- New insights about functional and cross-reactive properties of antibodies generated against recombinant TbpBs of Haemophilus parasuis.Scientific reports · 2017Article
- Article
- Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.Infection and immunity · 2015Article
- Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets.BioMed research international · 2015Article
- Virulence and draft genome sequence overview of multiple strains of the swine pathogen Haemophilus parasuis.PloS one · 2014Article
- Differences in Haemophilus parasuis adherence to and invasion of AOC-45 porcine aorta endothelial cells.BMC veterinary research · 2013Article
- Cross-protective efficacy of recombinant transferrin-binding protein A of Haemophilus parasuis in guinea pigs.Clinical and vaccine immunology : CVI · 2013Article
- Systems infection biology: a compartmentalized immune network of pig spleen challenged with Haemophilus parasuis.BMC genomics · 2013Article
- Haemophilus parasuis subunit vaccines based on native proteins with affinity to porcine transferrin prevent the expression of proinflammatory chemokines and cytokines in pigs.Clinical & developmental immunology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus parasuis is the agent responsible for causing Glässer's disease, which is characterized by fibrinous polyserositis, polyarthritis, and meningitis in pigs. In this study, we have characterized native outer membrane proteins with affinity to porcine transferrin (NPAPT) from H. parasuis serovar 5, Nagasaki strain. This pool of proteins was used as antigen to developed two vaccine formulations: one was adjuvanted with a mineral oil (Montanide IMS 2215 VG PR), while the other was potentiated with a bacterial neuraminidase from Clostridium perfringens. The potential protective effect conferred by these two vaccines was compared to that afforded by two other vaccines, consisting of recombinant transferrin-binding protein (rTbp) A or B fragments from H. parasuis, Nagasaki strain, and by a commercially available inactivated vaccine. Five groups of colostrum-deprived piglets immunized with the vaccines described above, one group per each vaccine, and a group of nonvaccinated control animals were challenged intratracheally with a lethal dose (3 × 10⁸ CFU) of H. parasuis, Nagasaki strain. The two vaccines containing rTbps yielded similar results with minimal protection against death, clinical signs, gross and microscopic lesions, and H. parasuis invasion. In contrast, the two vaccines composed of NPAPT antigen and commercial bacterin resulted in a strong protection against challenge (without deaths and clinical signs), mild histopathological changes, and no recovery of H. parasuis, thus suggesting their effectiveness in preventing Glässer's disease outbreaks caused by serovar 5.
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