ArticleMolecular biology of the cell2010
C-jun inhibits mammary apoptosis in vivo.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
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- A Lower Serum Antioxidant Capacity as a Distinctive Feature for Women with HER2+ Breast Cancer: A Preliminary Study.Cancers · 2022Article
- The Renaissance of CDK Inhibitors in Breast Cancer Therapy: An Update on Clinical Trials and Therapy Resistance.Cancers · 2022Review
- Identification of hub genes in chronically hypoxic myocardium using bioinformatics analysis.Molecular medicine reports · 2019Article
- CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.Nature communications · 2017Article
- Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.The American journal of pathology · 2015Article
- The role of SUMO-1 in cardiac oxidative stress and hypertrophy.Antioxidants & redox signaling · 2014Article
- Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice.International journal of cancer · 2014Article
- Manganese superoxide dismutase in cancer prevention.Antioxidants & redox signaling · 2014Review
- Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.Antioxidants & redox signaling · 2014Review
- Cyclin D1 determines estrogen signaling in the mammary gland in vivo.Molecular endocrinology (Baltimore, Md.) · 2013Article
- MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression.Oncogene · 2013Article
- Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells.Toxicology and applied pharmacology · 2012Article
- Mammary gland selective excision of c-jun identifies its role in mRNA splicing.Cancer research · 2012Article
- The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.PloS one · 2012Article
- STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.Biochemical and biophysical research communications · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
c-jun, which is overexpressed in a number of human cancers encodes a critical component of the AP-1 complex. c-jun has been shown to either induce or inhibit cellular apoptosis. Germ line deletion of both c-jun alleles is embryonically lethal. To determine the role of the endogenous c-jun gene in apoptosis, we performed mammary epithelial cell-targeted somatic deletion using floxed c-jun (c-jun(f/f)) conditional knockout mice. Laser capture microdissection demonstrated endogenous c-jun inhibits expression of apoptosis inducing genes and reactive oxygen species (ROS)-reducing genes (MnSOD, catalase). ROS have been implicated in apoptosis and undergo enzymatic elimination via MnSOD and CuZnSOD with further detoxification via catalase. c-jun-mediated survival was in part dependent on ROS production. c-jun-mediated repression of MnSOD and catalase occurred via mitochondrial complex I and NOX I. Collectively, these studies define a pivotal role of endogenous c-jun in promoting cell survival via maintaining mitochondrial integrity and expression of the key regulators of ROS production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.