ArticlePlant physiology2010
A gain-of-function mutation of Arabidopsis cryptochrome1 promotes flowering.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Blue Light Receptor PHR2-Mediated Spectrum Antiviral Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Time-Resolved Native Mass Spectrometry Reveals Reversible Light-Driven Oligomerization of Arabidopsis Cryptochrome 1 and Its Antagonism by BIC1.Angewandte Chemie (International ed. in English) · 2026Article
- CRY1-GAIP1 complex mediates blue light to hinder the repression of PIF5 on AGL5 to promote carotenoid biosynthesis in mango fruit.Plant biotechnology journal · 2025Article
- The PeachSNP170K array facilitates insights into a large-scale population relatedness and genetic impacts on citrate content and flowering time.Communications biology · 2025Article
- Research progress on delayed flowering under short-day condition inFrontiers in plant science · 2025Review
- Long-term effects of artificial nighttime lighting and trophic complexity on plant biomass and foliar carbon and nitrogen in a grassland community.Ecology and evolution · 2022Article
- Signaling Mechanisms by Arabidopsis Cryptochromes.Frontiers in plant science · 2022Review
- Article
- The Clock Gene TOC1 in Shoots, Not Roots, Determines Fitness ofPlant physiology · 2019Article
- Pivotal Roles of Cryptochromes 1a and 2 in Tomato Development and Physiology.Plant physiology · 2019Article
- Candidate Variants for Additive and Interactive Effects on Bioenergy Traits in Switchgrass (The plant genome · 2018Article
- Comparative RNA-Seq analysis on the regulation of cucumber sex differentiation under different ratios of blue and red light.Botanical studies · 2018Article
- Hyperactivity of theThe Journal of biological chemistry · 2017Article
- Cryptochrome 2 extensively regulates transcription of the chloroplast genome in tomato.FEBS open bio · 2017Article
- Cryptochromes Orchestrate Transcription Regulation of Diverse Blue Light Responses in Plants.Photochemistry and photobiology · 2017Review
- Arabidopsis cryptochrome 1 functions in nitrogen regulation of flowering.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- BRR2a Affects Flowering Time via FLC Splicing.PLoS genetics · 2016Article
- Signaling mechanisms of plant cryptochromes in Arabidopsis thaliana.Journal of plant research · 2016Review
- Plant flavoprotein photoreceptors.Plant & cell physiology · 2015Review
- Cellular metabolites enhance the light sensitivity of Arabidopsis cryptochrome through alternate electron transfer pathways.The Plant cell · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants use different classes of photoreceptors to collect information about their light environment. Cryptochromes are blue light photoreceptors that control deetiolation, entrain the circadian clock, and are involved in flowering time control. Here, we describe the cry1-L407F allele of Arabidopsis (Arabidopsis thaliana), which encodes a hypersensitive cryptochrome1 (cry1) protein. Plants carrying the cry1-L407F point mutation have elevated expression of CONSTANS and FLOWERING LOCUS T under short-day conditions, leading to very early flowering. These results demonstrate that not only the well-studied cry2, with an unequivocal role in flowering promotion, but also cry1 can function as an activator of the floral transition. The cry1-L407F mutants are also hypersensitive toward blue, red, and far-red light in hypocotyl growth inhibition. In addition, cry1-L407F seeds are hypersensitive to germination-inducing red light pulses, but the far-red reversibility of this response is not compromised. This demonstrates that the cry1-L407F photoreceptor can increase the sensitivity of phytochrome signaling cascades. Molecular dynamics simulation of wild-type and mutant cry1 proteins indicated that the L407F mutation considerably reduces the structural flexibility of two solvent-exposed regions of the protein, suggesting that the hypersensitivity might result from a reduced entropic penalty of binding events during downstream signal transduction. Other nonmutually exclusive potential reasons for the cry1-L407F gain of function are the location of phenylalanine-407 close to three conserved tryptophans, which could change cry1's photochemical properties, and stabilization of ATP binding, which could extend the lifetime of the signaling state of cry1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.