ArticleJournal of neurophysiology2010
Synchrony in normal and focal epileptic brain: the seizure onset zone is functionally disconnected.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects.Frontiers in neuroscience · 2022Pooled it
- Early seizure spread and epilepsy surgery: A systematic review.Epilepsia · 2020Pooled it
- Can REM Sleep Localize the Epileptogenic Zone? A Systematic Review and Analysis.Frontiers in neurology · 2020Pooled it
- Directed graph neural networks with partial directed coherence for seizure prediction and epileptogenic network characterization.iScience · 2026Article
- Interhemispheric Functional Hypoconnectivity Is an Early Marker of Cortical Epileptogenesis.Biomedicines · 2026Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Reproducibility of temporally evolving seizure patterns and network connectivity in focal epilepsy.Frontiers in neurology · 2025Article
- Directionality of neural activity in and out of the seizure onset zone in focal epilepsy.Network neuroscience (Cambridge, Mass.) · 2025Article
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study.Scientific reports · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Predicting radiofrequency thermocoagulation surgical outcomes in refractory focal epilepsy patients using functional coupled neural mass model.Frontiers in neurology · 2024Article
- Weak coupling of neurons enables very high-frequency and ultra-fast oscillations through the interplay of synchronized phase shifts.Network neuroscience (Cambridge, Mass.) · 2024Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
- Article
- Epileptic seizure focus detection from interictal electroencephalogram: a survey.Cognitive neurodynamics · 2023Review
- Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially.Nature communications · 2022Article
- Interictal Functional Connectivity in Focal Refractory Epilepsies Investigated by Intracranial EEG.Brain connectivity · 2022Review
- Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder.International journal of molecular sciences · 2022Review
- Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.Journal of neural engineering · 2022Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Synchronization of local and distributed neuronal assemblies is thought to underlie fundamental brain processes such as perception, learning, and cognition. In neurological disease, neuronal synchrony can be altered and in epilepsy may play an important role in the generation of seizures. Linear cross-correlation and mean phase coherence of local field potentials (LFPs) are commonly used measures of neuronal synchrony and have been studied extensively in epileptic brain. Multiple studies have reported that epileptic brain is characterized by increased neuronal synchrony except possibly prior to seizure onset when synchrony may decrease. Previous studies using intracranial electroencephalography (EEG), however, have been limited to patients with epilepsy. Here we investigate neuronal synchrony in epileptic and control brain using intracranial EEG recordings from patients with medically resistant partial epilepsy and control subjects with intractable facial pain. For both epilepsy and control patients, average LFP synchrony decreases with increasing interelectrode distance. Results in epilepsy patients show lower LFP synchrony between seizure-generating brain and other brain regions. This relative isolation of seizure-generating brain underlies the paradoxical finding that control patients without epilepsy have greater average LFP synchrony than patients with epilepsy. In conclusion, we show that in patients with focal epilepsy, the region of epileptic brain generating seizures is functionally isolated from surrounding brain regions. We further speculate that this functional isolation may contribute to spontaneous seizure generation and may represent a clinically useful electrophysiological signature for mapping epileptic brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.