ArticleJournal of neurophysiology2010
Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Impaired touch sensation on hairy skin in HCN3-deficient mice.Frontiers in neuroscience · 2025Article
- Self-other distinction modulates the social softness illusion.Psychological research · 2022Article
- When Differential Descending Control of Speed Matters: Descending Modulation of A- versus C-Fiber Evoked Spinal Nociception.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
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- Systemic growth hormone deficiency causes mechanical and thermal hypersensitivity during early postnatal development.IBRO reports · 2019Article
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- Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing.Neuroscience · 2018Article
- Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior.Neuroscience letters · 2016Article
- Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature.Journal of neurophysiology · 2016Article
- CaMKII Controls Whether Touch Is Painful.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.Journal of neurophysiology · 2015Article
- Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats.Pain · 2014Article
- The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input.The Journal of physiology · 2014Article
- Age-dependent sensitization of cutaneous nociceptors during developmental inflammation.Molecular pain · 2014Article
- Mechanical allodynia in human glabrous skin mediated by low-threshold cutaneous mechanoreceptors with unmyelinated fibres.Experimental brain research · 2013Article
- Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.Journal of neurophysiology · 2012Article
- Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Article
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- Seeding of breast cancer cell line (MDA-MB-231Molecular painArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sensory afferents in skin encode and convey thermal and mechanical conditions, including those that threaten tissue damage. A small proportion of skin, the glabrous skin of the distal extremities, is specialized to explore the environment in fine detail. Aside from increased innervation density, little is known regarding properties of mechanosensory afferents to glabrous skin in younger animals that explain the exquisite precision and high contrast in rapidly sampling physical structures, including those that threaten injury. To assess this, we obtained intact neuronal intracellular recordings in vivo from 115 mechanosensitive afferent neurons from lumbar and thoracic dorsal root ganglia in juvenile rats. Two characteristics were unique to glabrous skin: a threefold higher proportion of fast-conducting to slow-conducting afferents that were high-threshold mechanosensitive nociceptors compared with hairy skin and a twofold faster conduction velocity of fast-conducting nociceptors compared with hairy skin. Additionally differences were found in mechanical thresholds between glabrous skin and hairy skin for each fiber type. These differences reflect and help explain the rapid response of skin specialized to explore the physical environment. Additionally, these results highlight potential limitations of using passive electrical properties and conduction velocity alone to characterize primary afferents without knowledge of the skin type they innervated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.