ArticleJournal of virology2010
Multiple functions of Rice dwarf phytoreovirus Pns10 in suppressing systemic RNA silencing.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- Mutations in the WG and GW motifs of the three RNA silencing suppressors of grapevine fanleaf virus alter their systemic suppression ability and affect virus infectivity.Frontiers in microbiology · 2024Article
- Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense.International journal of molecular sciences · 2023Review
- TYMV and TRV infect Arabidopsis thaliana by expressing weak suppressors of RNA silencing and inducing host RNASE THREE LIKE1.PLoS pathogens · 2023Article
- RNAi-Based Antiviral Innate Immunity in Plants.Viruses · 2022Review
- Small RNAs Participate in Plant-Virus Interaction and Their Application in Plant Viral Defense.International journal of molecular sciences · 2022Review
- Contribution of Small RNA Pathway to Interactions of Rice with Pathogens and Insect Pests.Rice (New York, N.Y.) · 2021Review
- Rice Dwarf Virus Small RNA Profiles in Rice and Leafhopper Reveal Distinct Patterns in Cross-Kingdom Hosts.Viruses · 2019Article
- Roles of Small RNAs in Virus-Plant Interactions.Viruses · 2019Review
- Transcriptomic changes in3 Biotech · 2019Article
- Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice.PLoS pathogens · 2017Article
- MicroRNAs in Rice Innate Immunity.Rice (New York, N.Y.) · 2016Article
- Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development.PLoS pathogens · 2016Article
- Diverse Functions of Small RNAs in Different Plant-Pathogen Communications.Frontiers in microbiology · 2016Review
- OsRDR6 plays role in host defense against double-stranded RNA virus, Rice Dwarf Phytoreovirus.Scientific reports · 2015Article
- Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA.eLife · 2015Article
- Biogenesis, Function, and Applications of Virus-Derived Small RNAs in Plants.Frontiers in microbiology · 2015Review
- Overexpression of rice black-streaked dwarf virus p7-1 in Arabidopsis results in male sterility due to non-dehiscent anthers.PloS one · 2013Article
- Life cycle of phytoreoviruses visualized by electron microscopy and tomography.Frontiers in microbiology · 2013Review
- Validation of reference genes for gene expression studies in virus-infected Nicotiana benthamiana using quantitative real-time PCR.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing is a potent mechanism of antiviral defense response in plants and other organisms. For counterdefense, viruses have evolved a variety of suppressors of RNA silencing (VSRs) that can inhibit distinct steps of a silencing pathway. We previously identified Pns10 encoded by Rice dwarf phytoreovirus (RDV) as a VSR, the first of its kind from double-stranded RNA (dsRNA) viruses. In this study we investigated the mechanisms of Pns10 function in suppressing systemic RNA silencing in the widely used Nicotiana benthamiana model plant. We report that Pns10 suppresses local and systemic RNA silencing triggered by sense mRNA, enhances viral replication and/or viral RNA stability in inoculated leaves, accelerates the systemic spread of viral infection, and enables viral invasion of shoot apices. Mechanistically, Pns10 interferes with the perception of silencing signals in recipient tissues, binds double-stranded small interfering RNA (siRNAs) with two-nucleotide 3' overhangs, and causes the downregulated expression of RDR6. These results significantly deepen our mechanistic understanding of the VSR functions encoded by a dsRNA virus and contribute additional evidence that binding siRNAs and interfering with RDR6 expression are broad mechanisms of VSR functions encoded by diverse groups of viruses.
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