ArticleJournal of lipid research2011
Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity.Frontiers in immunology · 2026Article
- Association between atherogenic index of plasma and chronic diarrhea: a cross-sectional study of the NHANES 2005-2010.BMC gastroenterology · 2025Article
- High density lipoprotein-cholesterol is inversely associated with blood eosinophil counts among asthmatic adults in the USA: NHANES 2011-2018.Frontiers in immunology · 2023Article
- Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness.Journal of clinical medicine · 2021Review
- Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice.Frontiers in cardiovascular medicine · 2021Article
- Endothelial lipase increases antioxidative capacity of high-density lipoprotein.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action.Journal of atherosclerosis and thrombosis · 2018Review
- The role of endothelial lipase in lipid metabolism, inflammation, and cancer.Histology and histopathology · 2018Review
- Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Review
- Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.The Journal of biological chemistry · 2013Article
- Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Genetic and structure-function studies of missense mutations in human endothelial lipase.PloS one · 2013Article
- Crosstalk between reverse cholesterol transport and innate immunity.Trends in endocrinology and metabolism: TEM · 2012Review
- Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.Journal of atherosclerosis and thrombosis · 2012Article
- The role of HDL in innate immunity.Journal of lipid research · 2011Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that targeted deletion of endothelial lipase (EL) markedly increases the plasma high density lipoprotein cholesterol (HDL-C) level in mice. However, little is known about the functional quality of HDL particles after EL inhibition. Therefore, the present study assessed the functional quality of HDL isolated from EL(-/-) and wild-type (WT) mice. Anti-inflammatory functions of HDL from EL(-/-) and WT mice were evaluated by in vitro assays. The HDL functions such as PON-1 or PAF-AH activities, inhibition of cytokine-induced vascular cell adhesion molecule-1 expression, inhibition of LDL oxidation, and the ability of cholesterol efflux were similar in HDL isolated from WT and EL(-/-) mice. In contrast, the lipopolysaccharide-neutralizing capacity of HDL was significantly higher in EL(-/-) mice than that in WT mice. To evaluate the anti-inflammatory actions of HDL in vivo, lipopolysaccharide-induced systemic inflammation was generated in these mice. EL(-/-) mice showed higher survival rate and lower expression of inflammatory markers than WT mice. Intravenous administration of HDL isolated from EL(-/-) mice significantly improved the mortality after lipopolysaccharide injection in WT mice. In conclusion, targeted disruption of EL increased HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions. Thus, EL inhibition would be a useful strategy to raise 'good' cholesterol in the plasma.
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