ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2010
Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
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- CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis.The Journal of clinical investigation · 2025Article
- Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly.Communications biology · 2025Article
- NovelJournal of fungi (Basel, Switzerland) · 2023Article
- Concurrent Infection with SARS-CoV-2 andJournal of fungi (Basel, Switzerland) · 2022Review
- Sero-Epidemiology ofJournal of fungi (Basel, Switzerland) · 2022Article
- A therapeutic vaccine strategy to preventFrontiers in immunology · 2022Article
- Transmission and Colonization ofJournal of fungi (Basel, Switzerland) · 2021Review
- Diagnosis ofJournal of fungi (Basel, Switzerland) · 2020Article
- Pneumocystis primary infection in infancy: Additional French data and review of the literature.Medical mycology · 2020Article
- The Relationship betweenOBM genetics · 2018Article
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- Pneumocystis jirovecii--from a commensal to pathogen: clinical and diagnostic review.Parasitology research · 2015Review
- Review
- Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Humoral immune responses to Pneumocystis jirovecii antigens in HIV-infected and uninfected young children with pneumocystis pneumonia.PloS one · 2013Article
- Colonization by Pneumocystis jirovecii and its role in disease.Clinical microbiology reviews · 2012Review
- Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms.PloS one · 2012Article
- Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo characterize the seroepidemiological features of Pneumocystis jirovecii infection in healthy Chilean children using overlapping fragments (A, B, C) of the P. jirovecii major surface glycoprotein (Msg).
methodsSerum antibodies to MsgA, MsgB, and MsgC were measured every 2 months by enzyme-linked immunosorbent assay (ELISA) in 45 Chilean infants from about age 2 months to 2 years.
resultsPeak antibody levels (usually reached at age 6 months) and the force (or rate) of infection were somewhat greater for MsgC than for MsgA. Significant seasonal variation in antibody levels was only found with MsgA. Respiratory infections occurred in most children, but nasopharyngeal aspirates were of limited value in detecting the organism. In contrast, serological responses commonly occurred, and higher levels only to MsgC were significantly related to the number of infections.
conclusionsSerological responses to recombinant Msg fragments provide new insights into the epidemiological and clinical features of P. jirovecii infection of early childhood. MsgA, the amino terminus fragment, is more sensitive in detecting seasonal influences on antibody levels, whereas MsgC is better able to detect changes in antibody levels in response to clinical infection.
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