Evidence map›Paper›PMID 20926152›Full record

Trial reportDiabetes research and clinical practice2010

Asthma, chronic obstructive pulmonary disease, and type 2 diabetes in the Women's Health Study.

Yiqing Song, Anna Klevak, Joann E Manson, Julie E Buring, Simin Liu

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes research and clinical practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Vitamins C and E for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Pooled it
  5. Article
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  11. Diabetes-inducing effects of bronchial asthma.World journal of diabetes · 2025
    Article
  12. Article
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yiqing SongDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. ysong3@rics.bwh.harvard.edu
Anna Klevak
Joann E Manson
Julie E Buring
Simin Liu
Harvard University · USBrigham and Women's Hospital · US

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
Steroid Hormones, Adipose-cytokines, and Diabetes RiskR01DK066401 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, SIMIN · 2004 to 2008
$2.7M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
Magnesium Intake, Gene Variants, and Type 2 DiabetesK01DK078846 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SONG, YIQING · 2008 to 2010
$409k
NCI NIH HHS CA 047988NCI NIH HHS R01 CA047988NHLBI NIH HHS HL 043851NHLBI NIH HHS HL 080467NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NIDDK NIH HHS DK066401NIDDK NIH HHS K01 DK078846NIDDK NIH HHS K01-DK078846NIDDK NIH HHS R01 DK066401
6 · The paper itself

Abstract

backgroundChronic airway inflammation in asthma or chronic obstructive pulmonary disease (COPD) may be involved in the pathogenesis of type 2 diabetes; however, prospective data have been limited.

methodsA prospective cohort of 38,570 women who were aged ≥ 45 years, free of cardiovascular disease and cancer at baseline, and free of diabetes at baseline and in the first 12 months were analyzed. We classified all women into three groups according to the presence and absence of self-reported asthma or COPD (including emphysema, chronic bronchitis, and bronchiectasis).

resultsDuring a median follow-up of 12.2 years, 2472 incident type 2 diabetes events were documented. Women who had ever reported asthma or COPD were associated with an increased diabetes risk; the multivariate RRs were 1.37 (95% CI, 1.20-1.57) for women who had asthma alone and 1.38 (95% CI, 1.14-1.67) for COPD without asthmatic symptoms. Furthermore, these associations were not significantly modified by age, smoking status, physical activity, BMI, alcohol intake, hormone replacement therapy, menopausal status or randomized treatment.

conclusionsAsthma and COPD were individually and independently associated with an increased risk of type 2 diabetes in women, indicating that chronic airway inflammation may contribute to diabetes pathogenesis.

Indexed as

AspirinAsthmaBronchitis, ChronicCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansLongitudinal StudiesMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructivePulmonary EmphysemaRisk FactorsVitamin EAspirinVitamin E

Identifiers

PMID20926152
PMCPMC2993844
OpenAlexW2004735228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.