ArticleBiomaterials2011
The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 81 citations in OpenAlex.
- Isolation of functional human endothelial cells from small volumes of umbilical cord blood.Annals of biomedical engineering · 2013Trial
- What Are the Best Biocompatible Materials for Extracorporeal Membrane Oxygenation.Journal of functional biomaterials · 2025Review
- Integral Algorithms to Evaluate TiOInternational journal of molecular sciences · 2022Article
- Development of In Vitro Endothelialised Stents - Review.Stem cell reviews and reports · 2022Review
- Surface modification of decellularized bovine carotid arteries with human vascular cells significantly reduces their thrombogenicity.Journal of biological engineering · 2021Article
- Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO).Advanced composites and hybrid materials · 2021Review
- Hydrus microstent implantation for surgical management of glaucoma: a review of design, efficacy and safety.Eye and vision (London, England) · 2019Review
- Whole-Transcriptome Sequencing: a Powerful Tool for Vascular Tissue Engineering and Endothelial Mechanobiology.High-throughput · 2018Review
- Continuously Grooved Stent Struts for Enhanced Endothelial Cell Seeding.Cardiovascular and interventional radiology · 2017Article
- Point-of-care seeding of nitinol stents with blood-derived endothelial cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Antibacterial titanium nano-patterned arrays inspired by dragonfly wings.Scientific reports · 2015Article
- Increased yield of endothelial cells from peripheral blood for cell therapies and tissue engineering.Regenerative medicine · 2015Article
- Endothelial outgrowth cells: function and performance in vascular grafts.Tissue engineering. Part B, Reviews · 2014Review
- Article
- Surface projections of titanium substrates increase antithrombotic endothelial function in response to shear stress.Journal of biomedical materials research. Part A · 2013Article
- In vitro endothelialization of cobalt chromium alloys with micro/nanostructures using adipose-derived stem cells.Journal of materials science. Materials in medicine · 2013Article
- Immortalized functional endothelial progenitor cell lines from umbilical cord blood for vascular tissue engineering.Tissue engineering. Part C, Methods · 2012Article
- Retention of an autologous endothelial layer on a bioprosthetic valve for the treatment of chronic deep venous insufficiency.Journal of vascular and interventional radiology : JVIR · 2012Article
- Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device.Artificial organs · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 1 country.
Funding
Abstract
Implantable and extracorporeal cardiovascular devices are commonly made from titanium (Ti) (e.g. Ti-coated Nitinol stents and mechanical circulatory assist devices). Endothelializing the blood-contacting Ti surfaces of these devices would provide them with an antithrombogenic coating that mimics the native lining of blood vessels and the heart. We evaluated the viability and adherence of peripheral blood-derived porcine endothelial progenitor cells (EPCs), seeded onto thin Ti layers on glass slides under static conditions and after exposure to fluid shear stresses. EPCs attached and grew to confluence on Ti in serum-free medium, without preadsorption of proteins. After attachment to Ti for 15 min, less than 5% of the cells detached at a shear stress of 100 dyne / cm(2). Confluent monolayers of EPCs on smooth Ti surfaces (Rq of 10 nm), exposed to 15 or 100 dyne/cm(2) for 48 h, aligned and elongated in the direction of flow and produced nitric oxide dependent on the level of shear stress. EPC-coated Ti surfaces had dramatically reduced platelet adhesion when compared to uncoated Ti surfaces. These results indicate that peripheral blood-derived EPCs adhere and function normally on Ti surfaces. Therefore EPCs may be used to seed cardiovascular devices prior to implantation to ameliorate platelet activation and thrombus formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.