ArticleJournal of biomechanics2011
Mechanical recovery of dentin following remineralization in vitro--an indentation study.
Article in Journal of biomechanics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does delayed toothbrushing after the consumption of erosive foodstuffs or beverages decrease erosive tooth wear? A systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Methods for biomimetic remineralization of human dentine: a systematic review.International journal of molecular sciences · 2015Pooled it
- Article
- Adhesive Performance of Ion-Releasing Materials on Dentin with Altered Mineralization.Journal of functional biomaterials · 2026Article
- Biomimetic strategies for the dentin mineralization, using bioactive molecules: a scoping review and bibliometric analysis (2015-2025).Odontology · 2026Review
- Comparison of remineralization in caries-affected dentin using calcium silicate, glass ionomer cement, and resin-modified glass ionomer cement: an in vitro study.Restorative dentistry & endodontics · 2025Article
- Graphene and its modifications for enhanced adhesion in dental restoratives: a molecular docking and dynamics study.Scientific reports · 2025Article
- Impact of Demineralization Time on Enamel Microhardness Reduction and Lesion Depth: An In Vitro Study.Cureus · 2025Article
- Biomimetic remineralization of eroded dentin by synergistic effect of calcium phosphate and plant-based biomodifying agents: AnJournal of conservative dentistry and endodontics · 2024Article
- Dental biomaterials redefined: molecular docking and dynamics-driven dental resin composite optimization.BMC oral health · 2024Article
- Remineralization effects of enamel binding peptide, WGNYAYK, on enamel subsurface demineralizationHeliyon · 2024Article
- Effects of Ion-Releasing Materials on Dentine: Analysis of Microhardness, Appearance, and Chemical Composition.Materials (Basel, Switzerland) · 2023Article
- The Effect of Nanosilver Sodium Fluoride on the Mechanical and Physiochemical Properties of Artificially Demineralised Dentin.Oral health & preventive dentistry · 2023Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Chlorhexidine gluconate enhances the remineralization effect of high viscosity glass ionomer cement on dentin carious lesions in vitro.BMC oral health · 2022Article
- Article
- Polymer-Induced Liquid Precursor (PILP) remineralization of artificial and natural dentin carious lesions evaluated by nanoindentation and microcomputed tomography.Journal of dentistry · 2021Article
- Remineralization of Artificial Dentin LesionJournal of pharmacy & bioallied sciences · 2021Article
- Chemometrics-Assisted Raman Spectroscopy Characterization of Tunable Polymer-Peptide Hybrids for Dental Tissue Repair.Frontiers in materials · 2021Article
- Dentin Microhardness and Sealer Bond Strength to Root Dentin are Affected by Using Bioactive Glasses as Intracanal Medication.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study sought to gain insights into the steps leading to remineralization and mechanical recovery of hydrated dentin. Mechanical recovery in water was hypothesized to result from effective mineral matrix binding and to occur from the innermost regions outwards due to an increase in the number of nucleation sites. Partially demineralized (0.05 M acetate, pH=5.0, 8h) dentin was remineralized using calcium and phosphate solutions of 10.1 or 9.8 degree of saturation (DS) for hydroxyapatite (pH=7.4) for 4, 8 or 24h. Remineralization used a constant solution composition approach, which allowed for a continuous mineral growth with relatively constant thermodynamic driving forces. Crystal growth rates (R) were calculated using concentrations of calcium and phosphate. Before and after de- and re-mineralization, specimens had their surface and cross-section elastic moduli measured using AFM-nanoindentation in water. DS=10.1 provided higher R and higher mechanical recovery at the surface (p<0.0001). Cross-sectional measurements showed that subsurface mechanical recovery occurred from the innermost demineralized areas gradually outwards for both groups with no statistical differences at different DS, thus suggesting that remineralization is driven by mineral growth within nucleation sites with preserved collagen fibrils. Further, mechanical recovery appeared to initially obey a heterogeneous pattern, which vanished with time. This study provides evidence of mechanical recovery of hydrated dentin after remineralization and novel insights into the steps leading to mechanical recovery of carious dentin.
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Registered trials
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