Trial reportTrials2010
Exercise rehabilitation on home-dwelling patients with Alzheimer's disease--a randomized, controlled trial. Study protocol.
Trial report in Trials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Digital technology integration in home-based exercise: a systematic review of research evolution, applications, and impact mechanisms.BMC public health · 2025Pooled it
- Effectiveness of physiotherapy techniques on depressive symptoms in older adults: a systematic review.Frontiers in public health · 2025Pooled it
- Can non-pharmacological interventions reduce hospital admissions in people with dementia? A systematic review.PloS one · 2019Pooled it
- Effect of Exercise on Drug-Related Falls Among Persons with Alzheimer's Disease: A Secondary Analysis of the FINALEX Study.Drugs & aging · 2018Trial
- Importance of Modulating Kynurenic Acid Metabolism-Approaches for the Treatment of Dementia.Biomolecules · 2025Review
- External Validation of the 'International journal of environmental research and public health · 2020Article
- Current Update on Treatment Strategies for Idiopathic Normal Pressure Hydrocephalus.Current treatment options in neurology · 2019Review
- Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Evaluating the social fitness Programme for older people with cognitive problems and their caregivers: lessons learned from a failed trial.BMC geriatrics · 2018Article
- Physical activity, body mass index, and brain atrophy in Alzheimer's disease.Neurobiology of aging · 2015Article
- Gender differences in dementia spousal caregiving.International journal of Alzheimer's disease · 2012Article
- Cognitive function and the risk of death in chronic kidney disease.American journal of nephrology · 2012Article
- Stochastic resonance activity influences serum tryptophan metabolism in healthy human subjects.International journal of tryptophan research : IJTR · 2011Article
- How Do Community-Dwelling Persons with Alzheimer Disease Fall? Falls in the FINALEX Study.Dementia and geriatric cognitive disorders extraArticle
- Treatment of Alzheimer's disease in Brazil: II. Behavioral and psychological symptoms of dementia.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBesides cognitive decline, Alzheimer's disease (AD) leads to physical disability, need for help and permanent institutional care. The trials investigating effects of exercise rehabilitation on physical functioning of home-dwelling older dementia patients are still scarce. The aim of this study is to investigate the effectiveness of intensive exercise rehabilitation lasting for one year on mobility and physical functioning of home-dwelling patients with AD.
methodsDuring years 2008-2010, patients with AD (n = 210) living with their spousal caregiver in community are recruited using central AD registers in Finland, and they are offered exercise rehabilitation lasting for one year. The patients are randomized into three arms: 1) tailored home-based exercise twice weekly 2) group-based exercise twice weekly in rehabilitation center 3) control group with usual care and information of exercise and nutrition. Main outcome measures will be Guralnik's mobility and balance tests and FIM-test to assess physical functioning. Secondary measures will be cognition, neuropsychiatric symptoms according to the Neuropsychiatric Inventory, caregivers' burden, depression and health-related quality of life (RAND-36). Data concerning admissions to institutional care and the use and costs of health and social services will be collected during a two year follow-up. DISCUSSION: To our knowledge this is the first large scale trial exploring whether home-dwelling patients with AD will benefit from intense and long-lasting exercise rehabilitation in respect to their mobility and physical functioning. It will also provide data on cost-effectiveness of the intervention.
trial registrationACTRN12608000037303.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.