ArticleRespiratory research2010
Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- 4-Hydroxynonenal, a Potential Biomarker for Lung Inflammatory Diseases.International journal of molecular sciences · 2026Review
- Lung Regeneration by Transplantation of Allogeneic Lung Progenitors Using a Safer Conditioning Regimen and Clinical-grade Reagents.Stem cells translational medicine · 2022Article
- Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review.Journal of applied toxicology : JAT · 2022Review
- Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.Physiology (Bethesda, Md.) · 2021Review
- Toxic effects of chlorine gas and potential treatments: a literature review.Toxicology mechanisms and methods · 2021Review
- Halogen exposure injury in the developing lung.Annals of the New York Academy of Sciences · 2020Review
- Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome.Chinese medical journal · 2018Review
- Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse.British journal of pharmacology · 2017Article
- An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.Annals of the American Thoracic Society · 2017Article
- Nitrite therapy prevents chlorine gas toxicity in rabbits.Toxicology letters · 2017Article
- Persistent effects of chlorine inhalation on respiratory health.Annals of the New York Academy of Sciences · 2016Review
- Nitrite therapy improves survival postexposure to chlorine gas.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature.Toxicology · 2014Article
- Irritant-induced asthma in the workplace.Current allergy and asthma reports · 2014Review
- Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Evaluation of respiratory system mechanics in mice using the forced oscillation technique.Journal of visualized experiments : JoVE · 2013Article
- Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.Free radical biology & medicine · 2012Article
- Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram.Toxicology and applied pharmacology · 2012Article
- Irritancy and allergic responses induced by exposure to the indoor air chemical 4-oxopentanal.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundExposure to chlorine (Cl2) causes airway injury, characterized by oxidative damage, an influx of inflammatory cells and airway hyperresponsiveness. We hypothesized that Cl2-induced airway injury may be attenuated by antioxidant treatment, even after the initial injury.
methodsBalb/C mice were exposed to Cl2 gas (100 ppm) for 5 mins, an exposure that was established to alter airway function with minimal histological disruption of the epithelium. Twenty-four hours after exposure to Cl2, airway responsiveness to aerosolized methacholine (MCh) was measured. Bronchoalveolar lavage (BAL) was performed to determine inflammatory cell profiles, total protein, and glutathione levels. Dimethylthiourea (DMTU;100 mg/kg) was administered one hour before or one hour following Cl2 exposure.
resultsMice exposed to Cl2 had airway hyperresponsiveness to MCh compared to control animals pre-treated and post-treated with DMTU. Total cell counts in BAL fluid were elevated by Cl2 exposure and were not affected by DMTU treatment. However, DMTU-treated mice had lower protein levels in the BAL than the Cl2-only treated animals. 4-Hydroxynonenal analysis showed that DMTU given pre- or post-Cl2 prevented lipid peroxidation in the lung. Following Cl2 exposure glutathione (GSH) was elevated immediately following exposure both in BAL cells and in fluid and this change was prevented by DMTU. GSSG was depleted in Cl2 exposed mice at later time points. However, the GSH/GSSG ratio remained high in chlorine exposed mice, an effect attenuated by DMTU.
conclusionOur data show that the anti-oxidant DMTU is effective in attenuating Cl2 induced increase in airway responsiveness, inflammation and biomarkers of oxidative stress.
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Registered trials
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