Evidence map›Paper›PMID 20925595›Full record

SynthesisThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2011

Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression.

Janet M Wojcicki, Melvin B Heyman

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Dietary supplements for preventing postnatal depression.The Cochrane database of systematic reviews · 2013
    Pooled it
  2. Review
  3. Article
  4. Levels ofNutrients · 2020
    Article
  5. Management of Type 1 Diabetes in Pregnancy.Current diabetes reports · 2016
    Review
  6. Pharmacotherapy of postpartum depression: an update.Expert opinion on pharmacotherapy · 2014
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Janet M WojcickiDepartment of Pediatrics, University of California, San Francisco, CA, USA. wojcickij@peds.ucsf.edu
Melvin B Heyman
University of California, San Francisco · US

Funding

TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
Maternal Depression and Child Weight Gain in a Latino CohortK01DK080825 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOJCICKI, JANET M · 2009 to 2014
$721k
NIDDK NIH HHS K01 DK080825NIDDK NIH HHS T32 DK007762
6 · The paper itself

Abstract

objectiveA systematic review was conducted to assess the possible association between omega-3 polyunsaturated fatty acid (PUFA) supplementation and intake in the perinatal period and the risk of maternal perinatal depression.

methodsTwo PubMed searches and a BIOSIS Preview, a Web of Science and a PsychInfo search were conducted with the search terms 'DHA, pregnancy and depression' and 'omega-3 fatty acids, pregnancy and depression'.

resultsTen articles - three longitudinal cohort studies, five randomized controlled trials and two pilot trials- that met selection criteria were reviewed. Six found no association, two found mixed results, and two found a positive association between omega-3 PUFAs and reduced incidence of maternal perinatal depression. The heterogeneity of results can be explained by dissimilar study designs, including differences in study duration, time period of measurement and number of participants, and in varied dosages and types of supplemental PUFAs. Some of the larger studies and those that found a positive effect were more likely to be using higher doses, close to 2 g of docosahexaeonic acid (DHA) + eicosapentaenoic acid (EPA), and began the supplementation earlier in pregnancy.

conclusionsFuture RCTs to investigate the role of PUFA supplementation and risk for maternal perinatal depression should begin supplementation early in pregnancy and use a dosage closer to 2 g of DHA + EPA. Depression should also be measured using a diagnostic interview schedule in addition to a screener.

Indexed as

Depression, PostpartumDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidFemaleHumansLongitudinal StudiesPregnancyRandomized Controlled Trials as TopicRiskDocosahexaenoic AcidsEicosapentaenoic Acid

Identifiers

PMID20925595
PMCPMC3119925
OpenAlexW2006894847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.